Gabapentin
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Withdrawal syndrome: case report A 61-year-old man developed gabapentin withdrawal syndrome after gabapentin withdrawal. The man had chronic bilateral lower extremity pain secondary to diabetic neuropathy. He presented with nausea, vomiting, diaphoresis and diffuse myalgias, 3 days after discontinuing medication including high doses of gabapentin [route and dosage not stated] and oxycodone. Examination revealed extreme restlessness, elevated BP, confusion, diaphoresis and tremors. He was hospitalised, and treated with opioid analgesics and benzodiazepines for suspected opioid withdrawal syndrome. However, his symptoms continued over the following 10 hours, and he became more restless despite receiving morphine, lorazepam and haloperidol. About 24 hours after admission, gabapentin withdrawal was considered as part of the differential diagnosis. The man’s home dose of gabapentin was restarted. His mental status improved and his confusion and restlessness resolved over the following 36 hours. He was discharged on hospital day 3. Author comment: "Although not well documented, discontinuation of gabapentin can precipitate a specific withdrawal syndrome that can be easily confused with other more common withdrawal syndromes." Bonner WJ, et al. Gabapentin withdrawal syndrome: A case report. P M and R The Journal of Injury, Function and Rehabilitation 5 (Suppl.): S311, No. 9, Sep 2013. Available from: URL: http://dx.doi.org/10.1016/j.pmrj.2013.08.574 803095702 USA
0114-9954/13/1478-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
Reactions 16 Nov 2013 No. 1478
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