Gabapentin
- PDF / 141,733 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 13 Downloads / 184 Views
1
S
Myoclonus: case report A 57-year-old man experienced myoclonus while receiving gabapentin. The man, whose medical history included type 2 diabetes mellitus, hypertension and chronic kidney disease, was receiving gabapentin 900 mg/day [route, indication and duration of treatment not stated]. He presented to an emergency department with pain in his right foot. Investigations showed a blood urea nitrogen level of 81 mg/dL, a serum creatinine level of 6.3 mg/dL, a blood glucose level of 33 mg/dL, a bicarbonate level of 13 mg/dL, an anion gap of 14 mEq/L and a lactate level of 0.5 mEq/L. He was receiving a number of medications concomitantly; however, review of these did not identify any potential drug interactions. He became increasingly drowsy. Due to his electrolyte abnormalities and altered sensorium he was transferred to an ICU, where he was observed to have diffuse muscle twitches. His renal function was worsening acutely, and acute tubular necrosis was suspected. His serum gabapentin concentration was 6.3 µg/mL and gabapentin toxicity was suspected. The man received continuous renal replacement therapy (CRRT) for gabapentin toxicity, acute on chronic renal failure and metabolic abnormalities. CRRT was continued for approximately 3 days, until he started to produce urine. His symptoms improved significantly; his tremor resolved completely and his renal function improved. Author comment: "This case report demonstrates and underlines the roles of dialysis in the management of gabapentin-induced neurotoxicity in chronic renal failure patients." Guddati AK, et al. Treatment of gabapentin-induced myoclonus with continuous renal replacement therapy. Indian Journal of Nephrology 22: 59-61, No. 1, Jan-Feb 2012. Available from: URL: http://dx.doi.org/10.4103/0971-4065.83744 803074364 USA
0114-9954/10/1412-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 28 Jul 2012 No. 1412
Data Loading...
