Effect of molecular weight of regenerated silk fibroin on silk-based spheres for drug delivery
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pISSN: 0256-1115 eISSN: 1975-7220
INVITED REVIEW PAPER
INVITED REVIEW PAPER
Effect of molecular weight of regenerated silk fibroin on silk-based spheres for drug delivery Zengkai Wang*, Xiangming Li*, Yanhua Cui*, Kai Cheng*, Mingdong Dong**, and Lei Liu*,† *School of Materials Science and Engineering and Institute for Advanced Materials, Jiangsu University, Zhenjiang, 212013, China **Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000 Aarhus C, Denmark (Received 14 March 2020 • Revised 14 May 2020 • Accepted 27 May 2020) AbstractSilk fibroin presents a good advantage as a drug carrier for drug delivery, due to the excellent biocompatibility, biodegradability and tunable drug loading and release properties. In this work, we constructed silk spheres by phase separation of the regenerated silk fibroin (RSF) solutions with different MW and polyvinyl alcohol; and it was revealed that MW of RSF can affect the structure, size, surface potential and drug loading and release efficiency of silk spheres. Silk spheres prepared from high MW of RSF were found to load more macromolecular drug with negative charge compared to middle and low MW of RSF. However, for the positive charge and low MW drug, the silk spheres prepared from low MW of RSF could present a high loading efficiency compared to other carriers. Finally, a positive drug with low MW, streptomycin was encapsulated in silk spheres prepared from low MW of RSF, and displayed a long bactericidal and bacteriostatic effect compared to bared streptomycin solution. The results obtained provide guidelines for the modification and options of drug transport vehicles for more efficient drug delivery and utilization through a simple, rapidly constructed, applicable and low-cost drug carrier. Keywords: Silk Fibroin, Encapsulation and Release, Release Kinetics, Streptomycin, Antibactericidal Material
molecular weight (MW) of the polymer is also a key factor to the sizes, structures and mechanical properties and biodegradability of constructed materials [28,29], which could be significant in drug delivery. It was reported that the loading and release of a drug can be modulated and controlled by changing the MW of silk carriers. For instance, Mitropoulos et al. fabricated different size particles by microfluidics and using regenerated silk fibroin (RSF) with different MW to display distinct release features [21]. It is also found that the biological properties of a drug carrier could be significantly affected by modulating MW of SF carrier, e.g., the cell viability and the macrophage activation [30]. However, in most cases, a single MW drug carrier was used for different drugs without considering the drug properties and adaptability between the drug and drug carriers [3,31-33]. Therefore, a rational design of delivery system should be considered to load and release drug according to the different specific requirements, and general evaluation of release profiles of drug carriers according to different properties of drug molecule could be necessary. Many meth
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