Effect of Surgically Induced Weight Loss on Biomarkers of Endothelial Dysfunction: a Systematic Review and Meta-Analysis
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REVIEW
Effect of Surgically Induced Weight Loss on Biomarkers of Endothelial Dysfunction: a Systematic Review and Meta-Analysis Javad Seyyedi 1 & Shahab Alizadeh 2
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background This meta-analysis was performed to assess the effects of bariatric surgery (BS) on the selected markers of endothelial dysfunction, including monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin. Methods PubMed, Scopus, and Google scholar were systematically searched to identify related studies published from inception to November 2019 to find eligible studies. Results A total of 29 different studies were included. BS reduced the concentrations of MCP-1 (weighted mean difference (WMD) = − 58.91; 95%CI (confidence interval), − 77.10 to − 40.72; P = ˂ 0.001), ICAM-1 (WMD = − 36.58; 95%CI, − 49.65 to − 23.52; P = ˂ 0.001), and E-selectin (WMD = − 11.22; 95%CI, − 14.43 to − 8.01; P < 0.001), but had no significant effect on VCAM-1. Conclusion Bariatric surgery reduces circulating concentration of MCP-1, ICAM-1, and E-selectin, but not VCAM-1. Keywords Bariatric surgery . Endothelial dysfunction . MCP-1 . ICAM-1 . E-selectin . VCAM-1
Introduction Obesity is a multifactorial condition that is increasing rapidly and, nowadays, has become a chief health issue globally [1]. Not only severe obesity, defined as body mass index (BMI) more than 40 kg/m2, is contributed to the increased risk of cardiovascular diseases (CVD), cancer, dyslipidemia, type 2 diabetes, and mortality [2] but also negatively affects quality of life and self-esteem of individuals which could result in social withdrawal and severe depression [3]. Because of the unfavorable impacts of obesity on health, obese people try different therapeutic approaches to lose weight. As available pharmacotherapy and traditional recommendations to change Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11695-020-04710-1) contains supplementary material, which is available to authorized users. * Shahab Alizadeh [email protected] 1
Department of Medical Surgical Nursing, School of Nursing & Midwifery, Tehran University of Medical Sciences, Tehran, Iran
2
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
lifestyle-related factors such as following a strict diet or exercise had been unsuccessful to be completely effective [4], people have looked for a novel more comfortable approach to get rid of all extra adiposity [5]. Bariatric surgery (BS) is the most effective treatment for severe obesity [6], which results in significant weight loss at 1 year after surgery (about 60– 70% of extra weight) [7]. Furthermore, long-term investigations demonstrated it beneficial for improving a variety of diseases like atherosclerotic cardiovascular diseases [8]. The mechanisms by which BS improves CVD outcom
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