Effect of weight-loss diet combined with taurine supplementation on body composition and some biochemical markers in obe
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ORIGINAL ARTICLE
Effect of weight‑loss diet combined with taurine supplementation on body composition and some biochemical markers in obese women: a randomized clinical trial Fatemeh Haidari1 · Maryam Asadi2 · Javad Mohammadi‑Asl3 · Kambiz Ahmadi‑Angali4 Received: 31 December 2019 / Accepted: 19 July 2020 © Springer-Verlag GmbH Austria, part of Springer Nature 2020
Abstract Taurine (Tau), an endogenous non-protein and sulfuric-amino acid, is involved in various biological pathways including antiinflammatory, anti-oxidation, insulin resistance inhibition, and lipid profile improvement. According to some experimental and clinical studies, insulin resistance and excess body weight are associated with reduced serum level of Tau. Therefore, this study was aimed to evaluate Tau supplementation and a diet-induced weight-loss intervention on body composition and some biochemical indices of obese women. Participants were divided randomly into the intervention (standard weight-loss group + cap Tau 3 g/day for 8 weeks, n = 20) and control (standard weight-loss group + cap placebo for 8 weeks, n = 18) groups. To achieve weight loss, all participants received an individualized diet that included a 30% reduction in their total energy intake. Chi-square test was applied to compare categorical variables between two groups at baseline. Paired t test and independent-sample t test were also used to analyze the parametric continuous data within and between the two groups, respectively. Analysis of covariance was run for controlling the confounding variables. At the post-intervention, the mean changes of total cholesterol (p = 0.03), low-density lipoprotein cholesterol (p = 0.03), leptin (p = 0. 006), total adiponectin (p = 0.04), and high sensitivity C-reactive protein (p = 0.03) decreased significantly in Tau group compared with the control group. No significant results were found in the mean changes of high-density lipoprotein cholesterol, anthropometric measurements, glycemic indices, and liver enzymes between the two groups (p > 0.05). The findings showed that Tau supplementation along with a weight-loss diet may be more effective in improving the lipid profile and metabolic risk factors compared with a weight-loss diet alone. Keywords Taurine · Weight loss diet · Glycaemic indices · Lipid profile · Adipokines · Obesity Abbreviations ALT Alanine transferase AST Aspartate transaminase Handling editor: H. Jakubowski. * Maryam Asadi [email protected] 1
Department of Nutrition, Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2
Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3
Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4
Faculty of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Tau Taurine FBS Fasting blood sugar HOMA-IR Homeostatic model assessment of insulin resistance
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