Effect of zinc supplementation on type 2 diabetes parameters and liver metallothionein expressions in Wistar rats
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ORIGINAL PAPER
Effect of zinc supplementation on type 2 diabetes parameters and liver metallothionein expressions in Wistar rats Xue Wang & Hongyan Li & Zhe Fan & Ya Liu
Received: 21 October 2011 / Accepted: 19 April 2012 / Published online: 15 May 2012 # University of Navarra 2012
Abstract Zinc is a trace metal and acts as an active component of various enzymes. Zinc deficiency has been suggested to be associated with the development of diabetes. The present study investigated the role of zinc supplementation on prevention of diabetic conditions. A double-disease model mimicking hyperlipidemia and type 2 diabetes was created by applying highfat diet and streptozotocin (STZ) to Wistar rats. We demonstrated that zinc supplementation improved symptoms of diabetes such as polydipsia and increased serum level of high-density lipoprotein cholesterol, indicating that zinc supplementation has a potential beneficial effect on diabetic conditions. The level of maldondialdehyde (MDA), an oxidative stress marker, was reduced in liver by zinc supplementation in high fatfed rats with or without STZ injection. Meanwhile, we observed an increase in the expression of metallothioneins (MTs) in liver of rats treated with zinc. This X. Wang : Y. Liu (*) School of Republic Health, Jilin University, Changchun, People’s Republic of China 130021 e-mail: [email protected] X. Wang e-mail: [email protected] H. Li Graduate School of Jilin University, Changchun, People’s Republic of China 130021 Z. Fan Jilin Provincial People’s Procuratorate, Changchun, People’s Republic of China 130000
suggests that the induction of MTs in liver, which has been shown to be important in scavenging free radicals, could be one of the underlying mechanisms of zinc supplementation on reducing MDA levels in liver. Finally, we found that zinc levels in liver were increased while there was no change in serum zinc levels, indicating that local zinc level might be a critical factor for the induction of MTs. Also, the level of MTs could potentially be an index of zinc bioavailability. Taken together, these results suggest that both zinc and MT could play an important role in balancing nutrition and metabolism to prevent diabetic development. Keywords Zinc . Diabetes . Hyperglycemia . Dyslipidemia . Oxidative stress
Introduction Diabetes mellitus (DM) is a global public health problem which not only has a negative impact on the quality of life but also places a heavy financial burden to health care systems worldwide [27]. The prevalence of diabetes in China has been markedly increased during the last decade [31]. Type 2 diabetes, the most common form of diabetes, is mainly manifested as hyperglycemia and often associated with a cluster of metabolic disorders such as dyslipidemia and increased oxidative stress [12, 19]. The development of diabetes involves a chronic process which may be
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delayed or prevented through nutritional or lifestyle interventions. Zinc is a trace metal and acts as an active component of various enzymes. Zinc deficiency has been sugges
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