Zinc Supplementation Restores Altered Biochemical Parameters in Stomach Tissue of STZ Diabetic Rats
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Zinc Supplementation Restores Altered Biochemical Parameters in Stomach Tissue of STZ Diabetic Rats Ismet Burcu Turkyilmaz 1
&
Bertan Boran Bayrak 1 & Ozlem Sacan 1 & Ozgur Mutlu 1 & Nuriye Akev 2 & Refiye Yanardag 1
Received: 29 July 2020 / Accepted: 17 August 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract The stomach is among the organs grossly affected organ by diabetic complications. The present study was aimed at investigating the protective role of zinc on stomach of streptozotocin (STZ)-induced diabetes mellitus. Female Swiss albino rats were divided in four experimental groups: Group I, control; group II, control + zinc sulfate; group III, STZ-induced diabetic animals; and group IV, STZ-diabetic + zinc sulfate. Diabetes was induced by intraperitoneal injection of STZ, at a dose of 65 mg/kg body weight. Zinc sulfate (100 mg/kg body weight) was given daily by gavage for 60 days to groups II and IV. At the end of the experiment, the rats were sacrificed, and the tissues were taken. In the diabetic group, hexose, hexosamine, fucose, and sialic acid levels, as well as tissue factor, adenosine deaminase, carbonic anhydrase, xanthine oxidase, lactate dehydrogenase, prolidase activities, advanced oxidized protein products, homocysteine, and TNF-α levels were increased in the stomach tissue homogenates. Whereas, catalase, superoxide dismutase, glutathione-S-transferase, glutathione peroxidase, glutathione reductase, paraoxonase, and aryl esterase activities were decreased in the diabetic group. The administration of zinc reversed all the deformities. These findings suggest that zinc has protective role in ameliorating several mechanisms of STZ-induced diabetic stomach injury. Keywords Gastric tissue . Diabetes mellitus . Zinc . Glycoprotein . Oxidative stress
Introduction Diabetes mellitus is a metabolic disorder primarily associated with elevated levels of blood glucose. The elevation is as a result of deficiency or insufficient levels of insulin [1]. According to the reports of World Health Organization (WHO), it is estimated that the prevalence ratio of diabetes around the world will increase by 6% [2]. Many factors such as reactive oxygen species (ROS), abnormal functions of cell components, and impaired insulin secretion are associated with the onset and the progression of diabetes. These ultimately results to multiple organ failure and the degeneration of tissue functions such as in the stomach, lung, and liver [1–3].
* Ismet Burcu Turkyilmaz [email protected] 1
Department of Chemistry, Faculty of Engineering, Biochemistry Division, Istanbul University-Cerrahpasa, Avcilar, 34320 Istanbul, Turkey
2
Department of Biochemistry, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey
Hyperglycemia, an important factor in diabetes mellitus, is reported to alter antioxidant status, thereby favoring the accumulation of excessive ROS [4–6]. The elevated levels of oxidant like superoxide ions and hydroxyl radicals, thereafter, harm many organs and tissues [7].
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