Effects of acute and sub-acute hypobaric hypoxia on oxidative stress: a field study in the Alps
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ORIGINAL ARTICLE
Effects of acute and sub‑acute hypobaric hypoxia on oxidative stress: a field study in the Alps S. Mrakic‑Sposta1 · M. Gussoni2 · C. Dellanoce1 · M. Marzorati3 · M. Montorsi4 · L. Rasica3,5 · L. Pratali6 · G. D’Angelo6 · M. Martinelli7 · L. Bastiani6 · L. Di Natale8 · A. Vezzoli1 Received: 19 July 2020 / Accepted: 6 October 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose High altitude results in lower barometric pressure and hence partial pressure of O 2 decrease can lead to several molecular and cellular changes, such as generation of reactive oxygen species (ROS). Electron Paramagnetic Resonance technique was adopted in the field, to evaluate the effects of acute and sub-acute hypobaric hypoxia (HH) on ROS production by micro-invasive method. Biological biomarkers, indicators of oxidative stress, renal function and inflammation were investigated too. Methods Fourteen lowlander subjects (mean age 27.3 ± 5.9 years) were exposed to HH at 3269 m s.l. ROS production, related oxidative damage to cellular components, systemic inflammatory response and renal function were determined through blood and urine profile performed at 1st, 2nd, 4th, 7th, and 14th days during sojourn. Results Kinetics of changes during HH exposition showed out significant (range p
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