Efficacy and Tolerability of Prucalopride in Bowel Preparation for Colonoscopy: A Systematic Review and Meta-Analysis
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ORIGINAL RESEARCH
Efficacy and Tolerability of Prucalopride in Bowel Preparation for Colonoscopy: A Systematic Review and Meta-Analysis Sung-Wook Park . Seok-Pyo Shin . Ji Taek Hong
Received: February 8, 2020 Ó Springer Healthcare Ltd., part of Springer Nature 2020
ABSTRACT Introduction: Adequate bowel preparation is a vital determinant for the success of colonoscopy. However, individuals who undergo bowel preparation for colonoscopy can experience major discomfort. To solve this problem, adding prucalopride to the prepared solution may reduce intake volume, decreasing discomfort and side effects. We performed meta-analyses and systematic review of available randomized controlled trials. Methods: Meta-analyses were conducted to evaluate the overall relative risk and 95% confidence intervals in the combined studies for the assessment of primary outcome, which is the
Digital Features To view digital features for this article go to https://doi.org/10.6084/m9.figshare.12059349. Electronic Supplementary Material The online version of this article (https://doi.org/10.1007/s12325020-01333-x) contains supplementary material, which is available to authorized users. S.-W. Park Department of Internal Medicine, Nasaret International Hospital, Incheon, Korea S.-P. Shin J. T. Hong (&) Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea e-mail: [email protected]
efficacy of bowel preparation with the addition of prucalopride. Results: Four randomized controlled trials involving 581 patients were included. When data were pooled for all patients in two noninferiority studies, no significant difference in the quality of bowel preparation was observed between patients receiving prucalopride plus bowel preparation solution at a lower volume and those receiving the existing solution (relative risk: 0.94; 95% confidence interval: 0.86–1.03). The effects of prucalopride on acceptability, adverse events, adenoma detection rate, and polyp detection rate did not significantly differ from those of traditional solutions. Conclusions: The combination of prucalopride and bowel preparation solution at a lower volume has similar effects on bowel preparation, and its use did not increase the occurrence of adverse effects. Keywords: Bowel preparation; glycol; Prucalopride
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Key Summary Points Why carry out this study? Bowel cleansing is a major patient complaint during colonoscopy. The combination of prucalopride and the conventional preparation regimen may reduce the amount of bowel cleansing solution required for sufficient bowel cleansing or increase the bowel cleansing effect at the same dose. This study aimed to conduct systematic review and meta-analysis of randomized controlled trials to investigate the efficacy and tolerability of prucalopride in bowel preparation for colonoscopy. What was learned from the study? The combination of prucalopride and bowel preparation solution at a lower volume has similar effects on bowel cleansing, and its use did not increase the oc
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