Electrospun pH responsive poly (acrylic acid-co- acrylamide) hydrogel nanofibrous mats for drug delivery
- PDF / 1,735,210 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 76 Downloads / 229 Views
ORIGINAL PAPER
Electrospun pH responsive poly (acrylic acid-co- acrylamide) hydrogel nanofibrous mats for drug delivery Preeti Gupta 1 & Roli Purwar 1 Received: 26 March 2020 / Accepted: 26 May 2020 # The Polymer Society, Taipei 2020
Abstract In the present study hydrogel nanofibrous mats are prepared through electrospinning of poly (acrylamide-co-acrylic acid) dope solution having polyethylene glycol as cross-linker. The electrospun mats are heat treated at 150 °C to induce esterification crosslinking reaction. The mats are characterized for their structural, morphological and thermal behaviour. The average diameter of hydrogel nanofibers is found to be 275 ± 94.5 nm. The swelling behaviour of nanofibrous mats is evaluated in the phosphate buffer solutions of different pHs in the range of 2 to 8.5 and is found to be highest at neutral pH. The nanofibrous mats are loaded with amoxicillin drug for antimicrobial activity and drug release behaviour. The drug loaded mats form a clear inhibition zone with both Gram-positive bacteria S. aureus and Gram-negative bacteria E. coli in disc diffusion test. Drug is released at all the pHs (2 to 8.5) and maximum release is observed at neutral pH. The kinetics of drug release follows Fickian diffusion (n < 0.5) at tested pH. Keywords Hydrogel nanofibers . Drug release . Swelling behaviour . Poly (acrylic acid-co-acrylamide) . Fickian diffusion
Introduction Medicated hydrogels containing drugs/antibiotic, reduce the bacterial infection at wound site have built their interest to ameliorate the currently available wound healing processes [1–5]. Main features of hydrogels like porosity and swelling in aqueous media [6] can easily be modulated by regulating the closeness of cross-links in the hydrogel mats [7]. Porous framework also allows drug loading into the hydrogel mats and its subsequent exoneration at a rate relying on the diffusivity of the micro or macro molecules through the hydrogel network [8]. Electrospun nanofibrous mats have high surface to volume ratio, porous structure, good mechanical strength, more flexibility as compared to their film counterparts [9]. Inverse relation of the swelling kinetics of hydrogels films with the square of their dimensions suggests that the rate of volume change can be raised by altering the morphology of the hydrogel
* Roli Purwar [email protected] 1
Discipline of Polymer Science and Chemical Technology, Department of Applied Chemistry, Delhi Technological University, Shahabad Daulatpur, Bawana Road, Delhi 110042, India
material from films to nanofibrous form. Large surface area of hydrogel nanofibrous mats permits rapid discharge of antibiotics or growth factors at wound site [10, 11]. The highly porous framework of nanofibrous mats able do rapid body fluids absorption and waste diffusion. These alluring properties of hydrogel nanofibrous mats make them a potent candidate for medicated wound dressing material [12]. Recently, efforts have been made on designing the framework and composition for generating advance nanofibersroote
Data Loading...
