Synthesis and characterization of pH responsive alginate based-hydrogels as oral drug delivery carrier
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ORIGINAL PAPER
Synthesis and characterization of pH responsive alginate based-hydrogels as oral drug delivery carrier Pinar Ilgin 1
&
Hava Ozay 2 & Ozgur Ozay 2,3
Received: 18 December 2019 / Accepted: 26 May 2020 # The Polymer Society, Taipei 2020
Abstract As pharmaceutical carrier materials having antibacterial and pH-sensitive properties, hydrogels have great potential for clinical applications. Alginate based hydrogels were designed as an oral drug carrier and investigated for the drug release study in biomedical fields especially the colon-targeted system. Structural changes of synthesized hydrogel have been characterized using Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA) devices. Hydrogels have been studied for their water absorption behavior under the influence of various monomer compositions and changing ambient conditions such as salt, pH and temperature. In this study, diclofenac sodium was used as a model drug to investigate the in vitro release behavior at simulated intestinal (pH 7.0) and gastric fluid (pH 1.2). Lastly, the antibacterial effect of hydrogels and drug-loaded hydrogels was characterized using a disc diffusion method against Gram-positive and Gram-negative bacteria. The suitability of controlled drug release for the use of these new hydrogels in the pharmaceutical and biomedical field has been investigated and our results have shown that the produced hydrogels are promising materials for developing pHcontrolled drug delivery devices like capsules for oral use. Keywords Alginate . Hydrogel . Drug release . Swelling . Antimicrobial
Introduction Hydrogels are crosslinked network structures that have the ability to hold water by swelling in aqueous media due to the presence of hydrophilic groups like carboxyl groups, sulfonic acid groups and hydroxyl groups while preserving their three-dimensional structure. Their flexible and soft structures can mimic extracellular matrices which explains the large biomedical interest in hydrogels. In addition to chemical crosslinking of hydrogels, physical crosslinks may form with noncovalent interactions (like hydrophobic or ionic interactions, hydrogen bonds) between polymeric chains [1–5]. * Pinar Ilgin [email protected]; [email protected] 1
Department of Chemistry and Chemical Processing Technologies, Lapseki Vocational School, Canakkale Onsekiz Mart University, Canakkale/Lapseki, Turkey
2
Laboratory of Inorganic Materials, Department of Chemistry, Faculty of Science and Arts, Canakkale Onsekiz Mart University, Canakkale, Turkey
3
Department of Bioengineering, Faculty of Engineering, Canakkale Onsekiz Mart University, Canakkale, Turkey
Additionally, hydrogels can contain groups in their structure with sensor properties. Due to these groups in the structure, they respond to a variety of changes occurring in the environmental conditions like pH, temperature, ionic power, light, electrical and magnetic fields with adjustable physicochemical properties like sw
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