Enhanced antibacterial activity by silver nanoparticles-doped NiCo 2 O 4 nanosheets for the application of antibiotic re
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Bull Mater Sci (2020) 43:280 https://doi.org/10.1007/s12034-020-02266-5
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Enhanced antibacterial activity by silver nanoparticles-doped NiCo2O4 nanosheets for the application of antibiotic resistance CUIE SHI1,2, SHOUBAO YAN1,2,* , WENLONG SONG1,2, JIAN GAO1,2 and YING WANG1,2 1
School of Biologic Engineering, Huainan Normal University, Huainan 232038, People’s Republic of China Key Laboratory of Bioresource and Environmental Biotechnology of Anhui Higher Education Institutes, Huainan Normal University, Huainan 232038, People’s Republic of China *Author for correspondence ([email protected]) 2
MS received 12 February 2020; accepted 19 June 2020 Abstract. Antibiotic resistance has increased to dangerous levels across the globe. A growing list of bacterial infections that lead to blood poisoning or foodborne disease now represent a clinical challenge due to the loss of antibiotic efficacy. Studies on the antibacterial performance of Ag nanoparticles and other transitional metal oxides have gained attention as alternative therapeutic strategies. In this study, NiCo2O4 and Ag/NiCo2O4 composites of different Ag content were synthesized through a simple co-precipitation method and assessed through transmission electron microscopy, X-ray diffraction and scanning electron microscopy. We found that the morphology of NiCo2O4 was unaffected by Ag addition. NiCo2O4 and Ag/NiCo2O4 composites containing different amounts of Ag were of a suitable size (*10 nm). The NiCo2O4 and Ag/NiCo2O4 composites showed potent activity against a range of disease-causing bacteria. Ag/NiCo2O4 composites with a low Ag content showed only weak antibacterial activity. These data highlight new strategies to overcome antibiotic resistance. Keywords.
1.
Ag/NiCo2O4 nanosheets; silver nanoparticles; antibacterial activity.
Introduction
The emergence of antibiotic-resistant bacteria represent a current threat to human health. In the face of excessive antibiotic use, the number of deaths related to bacterial infections will continue to rise as global resistance develops. Immediate intervention strategies and improved bacterial therapies are urgently required to combat this threat to global health. Ag nanoparticles are 1–100 nm in size and constitute a high percentage of Ag oxide due to their large ratio of surface-to-bulk Ag atoms. Ag nanoparticles have several practical applications [1,2], most notably their functionality as both catalysts and bacteriostatic agents [3,4]. Free Ag ions can reduce Ag nanoparticles in solution and permit their aggregation through conventional reduction methods [5,6]. However, an issue during production is that the number of Ag particles on the surface of the aggregates decreases, leading to a loss of catalytic and/or bactericidal activity. To overcome production issues, a variety of surfactants and functional materials have been assessed with the ultimate aim of preventing aggregation [7–9]. However, sample contamination remains a problem and the re-synthesized Ag na
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