Enzyme Physics
This book treats a new, far-from-fully-developed area of molecular biophysics-enzyme physics. An attempt is made to survey this field, but primary consideration is given tothreeprob lems under investigation in the Polymer Structure Labaratory of the Inst
- PDF / 17,049,591 Bytes
- 205 Pages / 431 x 649 pts Page_size
- 25 Downloads / 206 Views
Enzyme Physics Mikhail V. Vol'kenshtein Institute of Molecular Biology Academy of Seiences of the USSR, Moscow
Translated lrom the Russian
g:> Springer Science+Business Media, LLC 1969
Library of Congress Catalog Card Number 69-12546
The original Russian textwas published by Nauka Press in Moscow in 1967 as part of a series entitled Fizika Zhiznennykh protsessov (Physics of Life Processes) M uxau.11
BAaouMuposu~
BoAbKeHUJ.mea.H
~H3H~A ~EPMEHTOB
FIZIKA FERMENTOV ENZYME PHYSICS
ISBN 978-1-4899-2836-8 ISBN 978-1-4899-2834-4 (eBook) DOI 10.1007/978-1-4899-2834-4
© 1969 Springer Science+Business Media New York Originally published by Plenum Press,New York in 1969. All rights reserved No part of this publication may be reproduced in any form without written permission from the publisher.
FOREWORD This book treats a new, far-from-fully-developed area of molecular biophysics- enzyme physics. An attempt is made to survey this field, but primary consideration is given tothreeproblems under investigation in the Polymer Structure Labaratory of the Institue of High-Molecular Compounds, Academy of Seiences ofthe USSR. The first problern is the genetic coding of the biologically fun.ctional structure of proteins. Its solution is based on physical theories of hydrophobic interactions. The second problern is the conformational properties of proteins as the factor governing enzyme activity. The most direct methods for experimental investigation of questions in this area are optical, principally those involving natural and magnetic rotation of the plane of polarization. A substantial portion of the book concerns optical activity; the Faraday effect is discussed in an appendix. The third problern is the manifestation of the cooperative properties of enzymes in the kinetics of enzymatic reactions and the solution of complex kinetic problems. This problern is especially pressing in connection with research on allosteric enzymes, which are responsible for feedback in metabolic processes. An appendix describes a new method for solving kinetic problems, based on the theory of graphs. This volume extends and details certain of the ideas expressed in my previous book, Molecules and Life: An Introduction to Molecular Biophysics, which was published in this series in 1965. V
vi
FOREWORD
The writing of this book was directly connected with my participation in two winter schools on molecular biology in Dubna, both as a lecturer and as an auditor. I wish to thank my colleagues and graduate students I. A. Bolotina, B. N. Goi 'dshtein,D. S. Markovich, and Yu. A. Sharonov for their assistance in the preparation of this work. Special thanks is due to Academician A. E. Braunshtein for the valuable criticisms he offered after reading the manuscript. M. Vol'kenshtein Leningrad, May 1966
CONTENTS CHAPTER 1 Introduction
1
CHAPTER 2 Protein Structure . . . . . . . . . . . . . . . . . . . . . . .
5
CHAPTER 3 Hydrophobie Interactions and Protein Structure. • •
18
CHAPTER 4 Genetic Coding of Protein Structure. • • • • • • • • • •
30
Data Loading...
