Epidemiological characteristics of severe fever with thrombocytopenia syndrome in Hefei of Anhui Province: a population-
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ORIGINAL ARTICLE
Epidemiological characteristics of severe fever with thrombocytopenia syndrome in Hefei of Anhui Province: a population-based surveillance study from 2011 to 2018 Enqing You 1 & Ling Wang 2 & Lei Zhang 1 & Jinju Wu 1 & Kefu Zhao 1 & Fen Huang 2 Received: 20 July 2020 / Accepted: 2 November 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease caused by the SFTS virus (SFTSV) of family Phenuiviridae. Since the virus was first identified in 2009, it has been rapidly spread in many Asian countries including Myanmar, Korea, Japan, and central China. In this study, we investigated the epidemiological characteristics of SFTS patients in Hefei from 2011 to 2018. In addition, we conducted a serological survey of SFTSV-specific antibody among healthy residents of five counties. We performed a retrospective observational study of SFTS cases reported to Hefei Center for Disease Control and Prevention (CDC) during Jan 2011 to Dec 2018. Almost every patient completed a structure questionnaire including clinical examination, course of disease, and history of epidemiology. A total of 754 serum specimens were collected and tested for IgG antibody with double-antigen sandwich ELISA method. Of 257 cases reported during that period, 33 died, with a case fatality rate of 13.0%. We found no significant difference between 30 non-survivors and 198 survivors except for age. The overall rate of seropositivity for SFTSV antibodies among healthy residents were 20.16%. We demonstrated that living in hilly areas, direct contact with domestic livestock and knowledge of tick-borne disease were significantly associated with positive serology result. SFTSV infection was prevalent among farming-related populations. Our study identified a relatively high seroprevalence of SFTSV-specific antibody in healthy residents, which provided the basis for asymptomatic SFTSV infections. More attention should be given to susceptible population and prevent SFTSV outbreak in high-endemic areas. Keywords Severe fever with thrombocytopenia syndrome (SFTS) . Seroprevalence . Epidemiology . Tick-borne diseases . Hefei
Introduction Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease, firstly identified in 2009 in rural areas of Hunan and Hubei province in central China. The major clinical manifestations of SFTS include fever, thrombocytopenia, leukocytopenia, gastrointestinal symptoms, neurological symptoms, and multi-organ Enqing You and Ling Wang contributed equally to this work and should be considered as co-first authors. * Fen Huang [email protected] 1
Hefei Center for Disease Control and Prevention, 86 Luan Road, Luyang District, Hefei 230061, Anhui, China
2
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Shushan District, Hefei 230032, Anhui, China
dysfunction in severe cases [1, 2]. A total of 5360 laboratory-confirmed cases
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