Genetic diversity and evolutionary history of Korean isolates of severe fever with thrombocytopenia syndrome virus from
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BRIEF REPORT
Genetic diversity and evolutionary history of Korean isolates of severe fever with thrombocytopenia syndrome virus from 2013–2016 Mi‑ran Yun1 · Jungsang Ryou2 · Wooyoung Choi3 · Ju‑Yeon Lee2 · Sun‑Whan Park4 · Dae‑Won Kim1 Received: 19 December 2019 / Accepted: 10 June 2020 © The Author(s) 2020
Abstract Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV). Although SFTS originated in China, it is an emerging infectious disease with prevalence confirmed in Japan, Korea, and Vietnam. The full-length genomes of 51 Korean SFTSV isolates from 2013 to 2016 were sequenced, and the sequences were deposited into a public database (GenBank) and analyzed to elucidate the phylogeny and evolution of the virus. Although most of the Korean SFTSV isolates were closely related to previously reported Japanese isolates, some were closely related to previously reported Chinese isolates. We identified one Korean strain that appears to have resulted from multiple inter-lineage reassortments. Several nucleotide and amino acid variations specific to the Korean isolates were identified. Future studies should focus on how these variations affect virus pathogenicity and evolution. Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV), a member of the order Bunyavirales, family Phenuiviridae, genus Bandavirus (https ://talk.ictvonline.org/taxonomy). SFTS is a newly emerging infectious disease with its major clinical symptoms Handling Editor: Hideki Ebihara. * Sun‑Whan Park [email protected] * Dae‑Won Kim [email protected] 1
Pathogen Resource TF, Center for Infectious Diseases Research, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, 200 Osongsaengmyeong2‑ro, Heungdeok‑gu, Cheogju‑si, Chungbuk 28160, Republic of Korea
2
Division of Emerging Infectious Disease and Vector Research, Center for Infectious Diseases Research, Korea National Institute of Health, Korea Centers for Disease Control and Prevention, 187 Osongsaengmyeong2‑ro, Heungdeok‑gu, Cheogju‑si, Chungbuk 28160, Republic of Korea
3
Division of Viral Diseases, Center for Laboratory control of Infectious Disease, Korea Centers for Disease Control and Prevention, 187 Osongsaengmyeong2‑ro, Heungdeok‑gu, Cheogju‑si, Chungbuk 28160, Republic of Korea
4
Jeju National Quarantine Station, Korea Centers for Disease Control and Prevention, 356 Central Goverment office‑Jeju, 59 Cheongsa‑ro, Jeju‑si 63219, Republic of Korea
and laboratory findings including fever, thrombocytopenia, gastrointestinal symptoms, leukopenia, and elevated levels of serum hepatic enzymes. Patients with SFTS usually die from multiple organ failure, and the average fatality rate is 12%, although it has been reported to be as high as 30% in some areas [1–3]. SFTS was first reported in China, with additional cases subsequently confirmed in Japan, Korea, and, most recently, Vietnam [4]. Two cases with comparable symptoms caused by a similar virus, Heartland virus, were reported in the Uni
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