First Fatal Infection and Phylodynamic Analysis of Severe Fever with Thrombocytopenia Syndrome Virus in Jilin Province,
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LETTER
First Fatal Infection and Phylodynamic Analysis of Severe Fever with Thrombocytopenia Syndrome Virus in Jilin Province, Northeastern China Xu Zhang1 • Nina Wang1 • Zedong Wang2 • Lihe Che2 • Chen Chen2 • Wen-Zhong Zhao3
•
Quan Liu1
Received: 30 October 2019 / Accepted: 16 March 2020 Ó Wuhan Institute of Virology, CAS 2020
Dear Editor, Severe fever with thrombocytopenia syndrome (SFTS), caused by SFTS virus (SFTSV) in the genus Banyangvirus of the family Phenuiviridae, is an emerging tick-borne viral zoonosis (Liu et al. 2014). Typical clinical symptoms of SFTS include fever, headache, thrombocytopenia, and leukocytopenia (Yu et al. 2011). Since SFTSV was identified in 2009, it has been found in more than 20 provinces in China and is closely related to strains from Japan and South Korea (Kim et al. 2013; Takahashi et al. 2014). In Northeastern China, the disease was discovered in Liaoning Province in 2010 (Wang et al. 2016), and the virus was detected in Haemaphysalis longicornis in Jilin Province in 2013 (Liu et al. 2016). Here we describe the first fatal case of SFTS in Jilin Province and conduct phylodynamic analysis of SFTSV. The patient was a 51-years-old woman living in Ji’an city of Jilin Province, northeastern China. She collected Chinese medicinal herbs on the mountain during June Xu Zhang, Nina Wang and Zedong Wang have contributed equally to this work.
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12250-020-00228-z) contains supplementary material, which is available to authorized users. & Wen-Zhong Zhao [email protected] & Quan Liu [email protected] 1
School of Life Sciences and Engineering, Foshan University, Foshan 528225, China
2
The First Hospital of Jilin University, Changchun 130021, China
3
Key Laboratory of National Health and Family Planning Commission of China for Male Reproduction and Genetics, Family Planning Research Institute of Guangdong Province, Guangzhou 510600, China
24–25, 2018, and presented fever (with a maximum temperature of 39.4 °C) on June 28, followed by nausea, vomiting, diarrhea, and chills. Laboratory tests showed a low white-cell count of 1650 cells per cubic millimeter, and a low platelet count of 70,000 cells per cubic millimeter. Chest X-ray examination revealed bilateral lung texture enhancement. On July 1, the platelet count was decreased to 40,000 cells per cubic millimeter. On July 2 (day 4), the number of platelets, white blood cells, and neutrophils decreased continuously, and proteinuria, hematuria and occult blood appeared in the urine. On July 3 (day 5), the patient showed bilateral inguinal lymph node enlargement, multiple organ dysfunction and hypoproteinemia (Supplementary Figure S1). Leukopenia continued until day 7 and turned to a high level on day 8–9, and the same trend was observed in neutrophils, monocytes, basophils, and lymphocytes, which may be resulted from the application of glucocorticoid and
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