Cancer and Energy Balance, Epidemiology and Overview
Energy Balance and Cancer, Epidemiology and Overview is the first in a series of monographs to address the multiple facets of the world wide pandemic of overweight and obesity and its relation to cancer. This volume, authored by leading experts in their p
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Series Editor: Nathan A. Berger, Case Western Reserve University, Cleveland, OH, USA
For further volumes: http://www.springer.com/series/8282
Nathan A. Berger Editor
Cancer and Energy Balance, Epidemiology and Overview
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Editor Nathan A. Berger School of Medicine Center for Science, Health & Society Case Western Reserve University 10900 Euclid Avenue Cleveland OH 44106 USA [email protected]
ISBN 978-1-4419-5514-2 e-ISBN 978-1-4419-5515-9 DOI 10.1007/978-1-4419-5515-9 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010923799 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface: Associations and Challenges
In a series of landmark articles published in the New England Journal of Medicine [1, 2] and Nature Reviews [3] between 1999 and 2004, Dr. Eugenia “Jeanne” Calle alerted the entire scientific and medical community to the epidemiologic evidence providing definitive support for the association between body mass, all cause mortality, and cancer mortality. Based on results from a prospectively studied cohort of more than 900,000 US adults in the American Cancer Society, Cancer Prevention II Study, Jeanne identified the association of increased body mass index with death rate for all cancers combined, as well as for specific malignancies in both men and women. The ACS study showed that elevated body mass was associated with higher death rates from cancers of the esophagus, colon and rectum, liver, gallbladder, pancreas, kidney, non-Hodgkin’s lymphoma, and multiple myeloma. Trends were identified also for association of elevated BMI with deaths from prostate and stomach cancer in men and postmenopausal breast, uterus, cervix, and ovarian cancer in women. She put forth the alarming statistics that 14% of cancers in men and 20% of cancers in women were associated with obesity, all of which were of even greater concern due to th
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