Eslicarbazepine acetate
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Hyponatraemia and suicide: 5 case reports In a multicenter, non-interventional, prospective and observational study (Zebinix Effects in DEpendency of BAseline Conditions; ZEDEBAC study) involving 237 patients, five patients [ages and sexes not stated] were described, who developed hyponatraemia (n=4) or died after suicide attempt (n=1) in the setting of eslicarbazepine acetate for partial-onset seizures [dosages, routes and durations of treatments to reactions onsets not stated]. The patients with partial-onset seizures, started receiving eslicarbazepine acetate [Zebinix]. One of the 5 patients had been concomitantly receiving other medications. However, the patients developed hyponatraemia (4 patients) or died after suicide attempt (1 patient). Among the 4 paients having hyponatraemia, eslicarbazepine acetate was discontinued in two patients, 1 patient was hospitalised and 1 patient received symptomatic treatment; all these patients recovered. The fifth patient accomplished suicide, which was considered as related to eslicarbazepine acetate. Author comment: "Hyponatremia was reported as ADR [to eslicarbazepine acetate ]." "The fifth death was the suicide that was considered to be possibly related to [eslicarbazepine acetate] therapy". Weissinger F, et al. Effectiveness of eslicarbazepine acetate in dependency of baseline anticonvulsant therapy: Results from a German prospective multicenter clinical practice study. Epilepsy and Behavior 101: 2019. Available from: URL: 803438212 http://doi.org/10.1016/j.yebeh.2019.106574 - Germany
0114-9954/19/1782-0001/$14.95 Adis © 2019 Springer Nature Switzerland AG. All rights reserved
Reactions 7 Dec 2019 No. 1782
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