Low serum free thyroxine concentrations associate with increased arterial stiffness in euthyroid subjects: a population-
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ORIGINAL ARTICLE
Low serum free thyroxine concentrations associate with increased arterial stiffness in euthyroid subjects: a population-based cross-sectional study Jian Wang1 • Xuqin Zheng1 • Min Sun1 • Zhixiao Wang1 • Qi Fu1 • Yun Shi1 • Mengdie Cao1 • Zhenxin Zhu1 • Chuchen Meng1 • Jia Mao1 • Fan Yang1 • Xiaoping Huang1 • Jingjing Xu1 • Hongwen Zhou1 • Yu Duan1 Wei He1 • Mei Zhang1 • Tao Yang1 • The REACTION Study Group
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Received: 12 January 2015 / Accepted: 8 April 2015 Ó Springer Science+Business Media New York 2015
Abstract Some studies suggest that even in euthyroid subjects, thyroid function may affect arteriosclerotic risk factors. We aimed to determine whether thyroid hormones or thyroid autoantibodies are associated with arterial stiffness in middle-aged and elderly Chinese subjects with euthyroidism. A cross-sectional, population-based study was conducted in Nanjing, China. A total of 812 euthyroid subjects (mean age [56.75 ± 8.34] years; 402 men) without vascular disease and major arteriosclerotic risk factors were included. Clinical factors, oral glucose tolerance test results, homeostasis model assessment for insulin resistance (HOMA-IR) results, and serum levels of lipids, free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), and thyroid autoantibodies were measured. Arterial stiffness was assessed using brachial-ankle pulse wave velocity (baPWV). In Pearson correlation analyses, baPWV correlated inversely with FT4 (r = -0.146, P \ 0.001), but not with FT3 (r = 0.008, P = 0.816) or TSH (r = 0.055, P = 0.118). Subsequently, a multiple stepwise regression analysis revealed a significant and independent association of FT4 with baPWV in euthyroid subjects (b = -0.076, P = 0.005). After adjusting for potential cardiovascular risk factors, mean
Jian Wang, Xuqin Zheng, and Min Sun have contributed equally to this study. The members of the REACTION study group are listed in the Appendix. & Tao Yang [email protected] 1
Department of Endocrinology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China
diastolic blood pressure (DBP), HOMA-IR, and baPWV levels decreased across increasing FT4 quartiles (DBP, P \ 0.001; HOMA-IR, P \ 0.001; baPWV, P = 0.003). No difference in baPWV was observed between the positive and the negative thyroid antibody groups (15.23 ± 3.30 m/s vs. 15.73 ± 3.05 m/s, P [ 0.05). FT4 levels were inversely associated with arterial stiffness in euthyroid subjects. A prospective study is warranted to validate whether subjects with low-normal FT4 levels have a high incidence of cardiovascular disease. Keywords Free thyroxine Thyroid hormones Thyroid antibody Arterial stiffness Brachial-ankle pulse wave velocity
Introduction The impact of thyroid function on cardiovascular disease has recently gained much attention. For example, considerable evidence suggests that overt hypothyroidism is associated with atherosclerosis and ischemic heart disease [1]. The accelerated atherosclerosis observed in the con
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