Expression of multidrug resistance-associated proteins and their relation to postoperative individualized chemotherapy i
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WORLD JOURNAL OF SURGICAL ONCOLOGY
RESEARCH
Open Access
Expression of multidrug resistance-associated proteins and their relation to postoperative individualized chemotherapy in gastric cancer Pengfei Yu*, Yian Du, Xiangdong Cheng, Qiming Yu, Ling Huang and Ruizeng Dong
Abstract Background: Adjuvant chemotherapy could reduce residual tumor cells and prevent relapse, however, not all patients are suitable for adjuvant chemotherapy. Screening appropriate patients based on molecular markers for individualized adjuvant chemotherapy is necessary. Methods: Between June 2002 and June 2004, 119 patients who underwent radical gastrectomy were retrospectively analyzed. Some patients had adjuvant chemotherapy based on platinum and 5-FU for four to six cycles. Topoisomerase II (ToPo II) negative, multidrug resistance protein (MRP) positive and glutathione S-transferase π (GST-π) positive were regarded as three risk factors that may be associated with chemotherapy resistance and poor prognosis. Patients were divided into two groups: a high-risk group (≥2 risk factors) and a low-risk group (0.05). In the low-risk group, the 3-year survival rates of patients with/without chemotherapy were 81.2% and 51.5%, and the 5-year survival rates were 71.9% and 45.5%, respectively, these differences were statistically significant (P
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