Heterologous Expression of Membrane Proteins Methods and Protocols
This detailed volume encompasses chapters from leading experts in the area of membrane proteins who describe step-by-step protocols developed these last few years to improve the functional production and stabilization of recombinant integra
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Isabelle Mus-Veteau Editor
Heterologous Expression of Membrane Proteins Methods and Protocols Second Edition
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Heterologous Expression of Membrane Proteins Methods and Protocols Second Edition
Edited by
Isabelle Mus-Veteau Université Côte d’Azur, CNRS, IPMC, France
Editor Isabelle Mus-Veteau Université Côte d’Azur CNRS, IPMC, France
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-3635-9 ISBN 978-1-4939-3637-3 (eBook) DOI 10.1007/978-1-4939-3637-3 Library of Congress Control Number: 2016935861 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
Preface Integral membrane proteins (IMPs) account for roughly 30 % of all open reading frames in fully sequenced genomes. These proteins are of main importance to living cells. They are involved in fundamental biological processes like ion, water, or solute transport, sensing changes in the cellular environment, signal transduction, and control of cell-cell contacts required to maintain cellular homeostasis and to ensure coordinated cellular activity in all organisms. IMP dysfunctions are responsible for numerous pathologies like cancer, cystic fibrosis, epilepsy, hyperinsulinism, heart failure, hypertension, and Alzheimer’s disease. However, studies on these and other disorders are hampered by a lack of information about the involved IMPs. Thus, knowing the structure of IMPs and understanding their molecular mechanism not only is of fundamental biological interest but also holds great potential for enhancing human health. This is of paramount importance in the pharmaceutic
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