Extracellular matrix protein 1 is correlated to carcinogenesis and lymphatic metastasis of human gastric cancer
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WORLD JOURNAL OF SURGICAL ONCOLOGY
RESEARCH
Open Access
Extracellular matrix protein 1 is correlated to carcinogenesis and lymphatic metastasis of human gastric cancer Qiuwan Wu†, Xiaohong Li†, Haiyan Yang, Chuanhui Lu, Jun You* and Zhiming Zhang*
Abstract Background: Tumor-induced lymphangiogenesis is a crucial step in malignant invasion and metastasis. Extracellular matrix protein 1 (ECM1) was recently reported to play a role in lymphangiogenesis. In the present work, we aimed to evaluate the role of ECM1 in gastric cancer and examined whether aberrant expression of ECM1 increased the tumorigenic and metastatic potential of human gastric cancer. Methods: The mRNA and protein expression of ECM1 in gastric cancer specimen and the noncancerous counterparts from 77 patients were detected by real-time PCR and immunohistochemistry staining. Lymphatic microvessel density (LMVD) in the corresponding serial sections was assessed by counting the lymphatic microvessels labelled by D2-40. The correlations between ECM1 expression, LMVD, and the clinicopathological parameters were examined. Results: ECM1 protein expression was detected in 70.1% (54/77) of gastric cancer specimen, significantly higher than that in the corresponding counterparts (P
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