Fabrication of HAP/Ag/SSD ternary nanocomposite and its antibacterial properties
- PDF / 931,583 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 35 Downloads / 211 Views
ORIGINAL PAPER: NANO-STRUCTURED MATERIALS (PARTICLES, FIBERS, COLLOIDS, COMPOSITES, ETC.)
Fabrication of HAP/Ag/SSD ternary nanocomposite and its antibacterial properties Zhenying Ge1 Ping Li2 Binjie Li1,2 Yanbao Zhao2 ●
●
●
1234567890();,:
1234567890();,:
Received: 31 March 2020 / Accepted: 22 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Hydroxyapatite/silver/silver sulfadiazine ternary nanocomposite (HAP/Ag/SSD TNC) with a novel hierarchical structure was successfully fabricated as following steps. First, mesoporous hydroxyapatite (HAP) nanorods as carrier were synthesized by a facile hydrothermal method. Second, as one antibacterial agent, silver nanoparticles were designed to be loaded on the mesoporous HAP nanorods to produce HAP/silver nanorods. Third, silver sulfadiazine as the other antibacterial agent was in situ produced on the surface of HAP/silver nanorods to form HAP/Ag/SSD TNC. To estimate its antibacterial properties, minimum inhibitory concentration, minimal bactericidal concentration, and a filter paper inhibition zone experiments were conducted with three bacteria strains of gram-negative Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), and gram-positive Staphylococcus aureus (S. aureus). The results demonstrated that HAP/Ag/ SSD TNC exhibited outstanding and sustained antibacterial activities against P. aeruginosa in 48 h. Toward E. coli and S. aureus, HAP/Ag/SSD TNC displayed similar antibacterial abilities with that of HAP/silver nanorods. Therefore, HAP/Ag/ SSD TNC has the potential to be a new excellent antibacterial agent and extensively applied in the antibacterial field. Graphical Abstract Illustration of the general formation procedure of HAP/Ag/SSD TNC.
* Binjie Li [email protected] * Yanbao Zhao [email protected] 1
School of Basic Medical Sciences, Henan University, Kaifeng 475004, PR China
2
Engineering Research Center for Nanomaterials, Henan University, Kaifeng 475004, PR China
Journal of Sol-Gel Science and Technology
Keywords
Hydroxyapatite Silver Silver sulfadiazine Ternary nanocomposite Antibacterial properties ●
●
●
●
Highlights HAP/Ag/SSD TNC was successfully fabricated via a multistep method. ● HAP/Ag/SSD TNC with a hierarchical architecture contributes to the sustained antibacterial activities. ● HAP/Ag/SSD TNC displays excellent antibacterial activities due to the synergic antibacterial effects of Ag, Ag+ and SD. ● HAP/Ag/SSD TNC exhibits outstanding and sustained antibacterial activity against P. aeruginosa in 48 h. ●
1 Introduction Attentions for the development of novel antibacterial products have been attracting worldwide in the healthcare area [1–3]. Among various antibacterial agents, silver-based antibacterial agents gain much interest for their broad spectrum and excellent antibacterial effects, commonly in the form of metallic silver and silver salts [4–6]. Recently, Ag nanoparticles (Ag NPs) are more highly favorable owning to their outstanding performance in antibacterial fields [7,
Data Loading...
