Familial Papillary Thyroid Carcinoma (FPTC): a Retrospective Analysis in a Sample of the Bulgarian Population for a 10-Y
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Familial Papillary Thyroid Carcinoma (FPTC): a Retrospective Analysis in a Sample of the Bulgarian Population for a 10-Year Period Kalin Vidinov 1
&
Dragomira Nikolova 2
# Springer Science+Business Media New York 2016
Abstract In recent years, there are numerous reports indicating the presence of familial papillary carcinoma. Unfortunately, no genetic defect can be linked directly to the disease. In this study, we set the goal to make a retrospective analysis of the cases with papillary carcinoma in the Department of Endocrine Surgery for the past 10 years, to compare the characteristics of sporadic and familial forms of the disease and to find families with hereditary papillary carcinoma. The study included 810 pat ient s treat ed for t hyroid cancer in the Department of Endocrine Surgery, USBALE “Acad. Iv. Penchev” Hospital, between January 1, 2006 and December 31, 2015. We used chi square test to determine statistical significant difference. The data analysis and interpretation was performed on SPSS 20.0. Both groups had similar demographic distribution. We found that 587 patients have sporadic papillary carcinoma, while 147 have a relative with thyroid pathology in the first degree of kinship. In 8 patients, there was a blood relative with thyroid cancer. When we compared the two groups, we found statistically significant difference only in tumor size. There was no significant difference in aggressiveness of the thyroid cancer
* Kalin Vidinov [email protected] Dragomira Nikolova [email protected] 1
Department of Endocrine Surgery, CCEG, Medical Faculty, MU – , Sofia, Bulgaria
2
Department of Medical Genetics, Medical Faculty, Medical University Sofia, Zdrave 2 Str, 1463 Sofia, Bulgaria
(multifocality and lymph node metastasis). When analyzing the results, we identified 147 patients with a family history of thyroid disease (20%). In 8 patients (5.44%), we found at least one relative with papillary thyroid carcinoma. However, our study does not demonstrate any difference in the aggressiveness of familial and sporadic papillary thyroid carcinoma. Keywords Papillary thyroid carcinoma (PTC) . Family papillary thyroid carcinoma (FPTC) . Frequency . Statistical significance predisposition Thyroid carcinoma is the most common malignant pathology of the endocrine system. Most thyroid cancers are occurring sporadically, but some are hereditary in nature. Currently, it is believed that approximately 5– 10% of all thyroid carcinoma cases are hereditary [1]. A much higher proportion (25%) of all medullary thyroid carcinoma (MTC) are hereditary [2]. The familial forms of papillary thyroid cancer are rare and are divided into two groups [3]. The first group includes syndromes with dominance of non-thyroid tumors, such as familial adenomatous polyposis (FAP) and PTEN-hamartoma (classic Cowden syndrome). The second group includes familial syndromes in which dominates the papillary TC: “pure” familial papillary carcinomas (FPTC), those associated with renal cell carcinoma, and FPC with multinodular goiter [3, 4]. According
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