Feasibility and validation of estimating Global LV functional indices from limited projections using a Modified Simpson'
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Feasibility and validation of estimating Global LV functional indices from limited projections using a Modified Simpson's Algorithm Ramkumar Krishnamurthy*1, Amol Pednekar2, Benjamin Cheong3 and Raja Muthupillai3 Address: 1Rice University, Houston, TX, USA, 2Philips Health Care, Houston, TX, USA and 3St. Luke's Episcopal Hospital, Houston, TX, USA * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):O46
doi:10.1186/1532-429X-12-S1-O46
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/O46 © 2010 Krishnamurthy et al; licensee BioMed Central Ltd.
Introduction A stack of 10-12 cine SSFP slices covering the LV are typically acquired to estimate global LV function. But, in instances such as dobutamine stress MR, it is difficult to acquire 10-12 contiguous short axis slices, and acquisition is limited to cine imaging at three short-axis (located at basal, mid and apical portions of the LV), and three long axis orientations (2-, 3- and 4-chamber views) [1]. It is unclear if it is feasible obtain an estimate of global LV function, e.g., EDV, ESV, etc. from these limited views.
Purpose The purpose of this work is to test the feasibility of developing a modified Simpson's algorithm that can calculate LV volumes from a limited sub-set of cardiac cine MR images (three short-axis views, and one long axis view), and validate the algorithm in human subjects.
Methods Data acquisition: In 20 subjects (14 M, age: 38+9 years) a set of contiguous cardiac cine SSFP images in the shortaxis and in the three standard long-axis orientations were acquired at 1.5 T. The acquisition parameters were: TR(ms)/TE(ms)/flip: 3.2/1.6/60°; acquired voxel-size: 2.5 × 2.5 × 8 mm3; temporal resolution: 40-60 ms; breathhold time: 5-8 s/slice.
Figure LV mitral-valve of mid lengths slice length Cavity and andL2, 1apical the L1, Geometric and annulus the LVslices L3, apex two and to were regions was Model: basal themodeled moeled apical slice between The region was LV asastow cavity modeled athe cone between cut-cones basal between ofas and length the a mid, cylinder of the apical L4and LV Cavity Geometric Model: The LV cavity between the mitral-valve annulus to basal slice was modeled as a cylinder of length L1, the two regions between the basal and mid, and mid and apical slices were moeled as tow cut-cones of lengths L2, and L3, and the apical region between the apical slice and the LV apex was modeled as a cone of length L4. L1 and L4 were calculated directly from one of the long axis views, and the L2, and L3 were calcualted from the inter-slice gap presribed during acquisition.
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