Fluticasone propionate
- PDF / 169,965 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 80 Downloads / 200 Views
1 S
Epstein-Barr virus infection reactivation and oral hairy leukoplakia: case report A 9-year-old girl developed Epstein-Barr virus infection reactivation and oral hairy leukoplakia during treatment with fluticasone propionate for allergic rhinitis. The girl presented with a white lesion on the lateral border of her tongue, which had presented for an unspecified time. Her medical history included significant heart murmur and varicella at 4 years of age. She had been receiving treatment with fluticasone propionate nasal inhaler spray at 50 µg/day in each nostril for the previous 4 months for allergic rhinitis. She had no relevant family history. The intra-oral findings showed a white adherent plaque with striated areas on the right lateral border of the tongue extending from the ventral to the dorsal surfaces. On palpation, the plaque was rough and thick. Thus, she was clinically diagnosed with oral hairy leukoplakia. Microscopy of an incisional biopsy revealed hyperparakeratosis and bacterial colonisation on the surface. Also, keratinocytes with pale and oedematous cytoplasm with nuclei showing dispersed chromatin in a bead-like distribution at the nuclear membrane were noted under the stratum corneum. Chromogenic in situ hybridisation was positive for Epstein-Barr virus-RNA indicating Epstein-Barr virus infection reactivation and confirming the diagnosis of oral hairy leukoplakia secondary to fluticasone propionate [duration of treatment to reactions onsets not stated]. The girl was lost to follow-up [outcomes not stated]. Costa FH, et al. Oral hairy leukoplakia in a child using a corticosteroid nasal spray. Pediatric Dermatology 37: 721-723, No. 4, Jul-Aug 2020. Available from: URL: http:// 803498282 doi.org/10.1111/pde.14194
0114-9954/20/1819-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
Reactions 29 Aug 2020 No. 1819
Data Loading...
