Fragment-Based Drug Discovery and X-Ray Crystallography
D. A. Erlanson Introduction to Fragment-Based Drug Discovery T. G. Davies Ian J. Tickle Fragment Screening Using X-Ray Crystallography S. Roughley L. Wright P. Brough A. Massey R. E. Hubbard Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening D
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Topics in Current Chemistry
Editorial Board: K.N. Houk C.A. Hunter M.J. Krische J.-M. Lehn S.V. Ley M. Olivucci J. Thiem M. Venturi P. Vogel C.-H. Wong H. Wong H. Yamamoto l
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Fragment-Based Drug Discovery and X-Ray Crystallography
Volume Editors: Thomas G. Davies Marko Hyvo¨nen
With Contributions by E. Arnold J.D. Bauman P. Brough T.G. Davies H.L. Eaton D.A. Erlanson S. Greive M. Hennig W. Huber R.E. Hubbard M. Hyvo¨nen M. Marsh A. Massey D. Patel A. Ruf D. Rognan S. Roughley T. Sharpe A.W. Stamford C. Strickland I.J. Tickle E. Valkov J.H. Voigt Y.-S. Wang L. Wright D.F. Wyss Z. Zhu
Editors Dr. Thomas G. Davies Astex Pharmaceuticals 436 Cambridge Science Park Milton Road Cambridge CB4 0QA UK [email protected]
Dr. Marko Hyvo¨nen Department of Biochemistry University of Cambridge 80 Tennis Court Road Cambridge CB2 1GA UK [email protected]
ISSN 0340-1022 e-ISSN 1436-5049 ISBN 978-3-642-27539-5 e-ISBN 978-3-642-27540-1 DOI 10.1007/978-3-642-27540-1 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2011945781 # Springer-Verlag Berlin Heidelberg 2012 This work is subject to copyright. All rights are reserved, w
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