Fragment-Based Drug Discovery and X-Ray Crystallography

D. A. Erlanson Introduction to Fragment-Based Drug Discovery T. G. Davies Ian J. Tickle Fragment Screening Using X-Ray Crystallography S. Roughley L. Wright P. Brough A. Massey R. E. Hubbard Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening D

  • PDF / 62,589 Bytes
  • 12 Pages / 439.37 x 666.142 pts Page_size
  • 5 Downloads / 164 Views

DOWNLOAD

REPORT


Topics in Current Chemistry

Editorial Board: K.N. Houk C.A. Hunter M.J. Krische J.-M. Lehn S.V. Ley M. Olivucci J. Thiem M. Venturi P. Vogel C.-H. Wong H. Wong H. Yamamoto l

l

l

l

l

l

l

l

l

Topics in Current Chemistry Recently Published and Forthcoming Volumes

Fragment-Based Drug Discovery and X-Ray Crystallography Volume Editors: Thomas G. Davies, Marko Hyvo¨nen Vol. 317, 2012 Novel Sampling Approaches in Higher Dimensional NMR Volume Editors: Martin Billeter, Vladislav Orekhov Vol. 316, 2012

Fluorous Chemistry Volume Editor: Istva´n T. Horva´th Vol. 308, 2012 Multiscale Molecular Methods in Applied Chemistry Volume Editors: Barbara Kirchner, Jadran Vrabec Vol. 307, 2012 Solid State NMR Volume Editor: Jerry C. C. Chan Vol. 306, 2012

Advanced X-Ray Crystallography Volume Editor: Kari Rissanen Vol. 315, 2012

Prion Proteins Volume Editor: Jo¨rg Tatzelt Vol. 305, 2011

Pyrethroids: From Chrysanthemum to Modern Industrial Insecticide Volume Editors: Noritada Matsuo, Tatsuya Mori Vol. 314, 2012

Microfluidics: Technologies and Applications Volume Editor: Bingcheng Lin Vol. 304, 2011

Unimolecular and Supramolecular Electronics II Volume Editor: Robert M. Metzger Vol. 313, 2012 Unimolecular and Supramolecular Electronics I Volume Editor: Robert M. Metzger Vol. 312, 2012 Bismuth-Mediated Organic Reactions Volume Editor: Thierry Ollevier Vol. 311, 2012

Photocatalysis Volume Editor: Carlo Alberto Bignozzi Vol. 303, 2011 Computational Mechanisms of Au and Pt Catalyzed Reactions Volume Editors: Elena Soriano, Jose´ Marco-Contelles Vol. 302, 2011 Reactivity Tuning in Oligosaccharide Assembly Volume Editors: Bert Fraser-Reid, J. Cristo´bal Lo´pez Vol. 301, 2011

Peptide-Based Materials Volume Editor: Timothy Deming Vol. 310, 2012

Luminescence Applied in Sensor Science Volume Editors: Luca Prodi, Marco Montalti, Nelsi Zaccheroni Vol. 300, 2011

Alkaloid Synthesis Volume Editor: Hans-Joachim Kno¨lker Vol. 309, 2012

Chemistry of Opioids Volume Editor: Hiroshi Nagase Vol. 299, 2011

Fragment-Based Drug Discovery and X-Ray Crystallography

Volume Editors: Thomas G. Davies  Marko Hyvo¨nen

With Contributions by E. Arnold  J.D. Bauman  P. Brough  T.G. Davies  H.L. Eaton  D.A. Erlanson  S. Greive  M. Hennig  W. Huber  R.E. Hubbard  M. Hyvo¨nen  M. Marsh  A. Massey  D. Patel  A. Ruf  D. Rognan  S. Roughley  T. Sharpe  A.W. Stamford  C. Strickland  I.J. Tickle  E. Valkov  J.H. Voigt  Y.-S. Wang  L. Wright  D.F. Wyss  Z. Zhu

Editors Dr. Thomas G. Davies Astex Pharmaceuticals 436 Cambridge Science Park Milton Road Cambridge CB4 0QA UK [email protected]

Dr. Marko Hyvo¨nen Department of Biochemistry University of Cambridge 80 Tennis Court Road Cambridge CB2 1GA UK [email protected]

ISSN 0340-1022 e-ISSN 1436-5049 ISBN 978-3-642-27539-5 e-ISBN 978-3-642-27540-1 DOI 10.1007/978-3-642-27540-1 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2011945781 # Springer-Verlag Berlin Heidelberg 2012 This work is subject to copyright. All rights are reserved, w