Microarray Methods for Drug Discovery
While the utilization of microarrays for gene expression studies has been widely published, Microarray Methods for Drug Discovery describes the use of this technology for a multitude of other vital applications. Covering the field of drug discovery throug
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Molecular Biology™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
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Microarray Methods for Drug Discovery Edited by
Sridar V. Chittur Department of Biomedical Sciences, School of Public Health, Center for Functional Genomics, University at Albany-SUNY, Rensselaer, NY, USA
Editor Sridar V. Chittur, Ph.D. Department of Biomedical Sciences Schools of Public Health Centre for Functional Genomics University at Albany-SUNY Rensselaer, NY USA [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-60761-662-7 e-ISBN 978-1-60761-663-4 DOI 10.1007/978-1-60761-663-4 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010921137 © Humana Press, a part of Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is a part of Springer Science+Business Media (www.springer.com)
Preface The postgenomic era presents a multitude of challenges for scientists in all areas of science. The information overload from new discoveries in genomics and proteomics highlight how little we really know about the functioning of a cell. The advent of Next-Generation Sequencing technologies promises to make our genetic blueprint available to the common man. The availability of the plethora of biological information has lead to the development of new areas of science and the coining of new “omics” terms including transcriptomics, methylomics, toxicogenomics, pharmacogenomics, metabolomics, lipidomics, and so on. Remarkable research is being conducted to understand the various aspects of human health and how processes like histone modifications, promoter usage, alternative splicing, posttranscriptional, and posttranslational modifications contribute to disease. The advent of systems biology has unified chemists and biochemists alike in the struggle to
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