Frailty and Sarcopenia in Cirrhosis The Basics, the Challenges, and
This book provides a concise yet comprehensive overview of frailty and sarcopenia in the cirrhotic patient. The text presents a personalized approach to identifying cirrhotic patients at risk of higher morbidity and mortality due to frailty and sarcopenia
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Frailty and Sarcopenia in Cirrhosis
Puneeta Tandon • Aldo J. Montano-Loza Editors
Frailty and Sarcopenia in Cirrhosis The Basics, the Challenges, and the Future
Editors Puneeta Tandon Division of Gastroenterology and Liver Unit University of Alberta Edmonton AB Canada
Aldo J. Montano-Loza Division of Gastroenterology and Liver Unit University of Alberta Edmonton AB Canada
ISBN 978-3-030-26225-9 ISBN 978-3-030-26226-6 (eBook) https://doi.org/10.1007/978-3-030-26226-6 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Frailty and sarcopenia have long been recognized as essential elements for prognostication in the aging population. In the recent past, an ever-increasing number of studies have explored the prevalence, pathogenesis, and robust prognostic relevance in patients with cirrhosis. This rising tide of data has already resulted in a change in how we describe our patients, the terms frailty and sarcopenia now permeating our vocabulary. As an emerging area of study in cirrhosis, some important questions have been answered, but many questions remain. How can frailty and sarcopenia be measured? How do they behave over time? What are the changes in muscle cellular and molecular biology that result in atrophy and weakness? How should the information about a patient’s frailty or sarcopenia be used to guide rehabilitation? Should a diagnosis of frailty or sarcopenia change whether patients are considered for liver transplant? Recognizing the importance of these questions, it is our distinct pleasure to bring together the efforts of an international team of experts and share with you a practical review of “the basics, the challenges,
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