Functional Patternings Fabricated using Molecularly Imprinted Polymer; Molecular Recognitions for Chemical Detection
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0951-E12-37
Functional Patternings Fabricated using Molecularly Imprinted Polymer; Molecular Recognitions for Chemical Detection Kyung Choi Bell Labs, Murray Hill, NJ, 07974 We present functional micropatterns fabricated using functional polymers. The functional polymer is MIP (molecularly imprinted polymer), which can be produced by “molecular imprinting technique” to create “synthetic receptors or binding sites” for bio/chemical detective technology. Those binding sites have specific molecular recognition functions for targeting organic or bio molecules. MIP’s micropatterns have been integrated for fabricating chemical sensors, diagonostic bio-sensors, and for drug delivery systems. We also produced homogeneous MIP’s microparticles, which have high affinity receptor sites only by designing a microfluidic reactor.
INTRODUCTION Recent nanotechnology has brought us innovations to improve the quality of our lives.1-9 It also has tremendous potentials to create novel technological emergences, which could overcome the limitations in conventional developments. Nanotechnology is a highly multidisciplinary field, which requires contributions from chemists, physicist, materials scientists, and engineers. Recent developments in this area include soft lithography, plastic electronics, nanofabrications, and microfluidic approach. In nanotechnology, there are many challenges for chemists and materials scientists to contribute to this area by developing new materials; because, nanotechnology is a part of chemical domain, which builds up new materials for our diverse applications. Nanofabrication has been widely used to integrate nanopatterns by using organic/ inorganic materials to develop small devices fabricated on diverse substrates. Due to stringent needs for high fidelity lithography, incentive challenges in developing new materials currently lead this technology. Since chemists have been seeking for unconventional routes to synthesize novel functional materials, the development of high performance materials allows us to bring advances in this area to meet our growing demands in miniaturizations. We introduced here novel chemical approaches for functional patterning purposes. Functional patterns, which have specific molecular recognition, were fabricated on silicon wafers using photopatternable MIP’s polymers for sensor applications. Since detection is elicited by change in physicochemical properties of interface, the development of high affinity binding sites on molecules is a key contributor to the achievement of ‘monoclonal’ materials, which have high affinity sites only. To achieve high affinity in recognition functions from MIPs’ system, we employed soft lithography and MIMIC techniques using PDMS stamps to transfer patterns from masters to a variety of substrates (Figure 1).
(a)
UV lithography: expose the photosensitive material to light through a mask. Soft lithography: transferring patterns from the master to substrate by using a PDMS stamp.
PDMS Prepolymer
Cured PDMS Stamp or Mold
(b)
Figure 1. (a) Soft li
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