Gastric Cancer In The Precision Medicine Era Diagnosis and Therapy

This book provides a comprehensive, state-of-the art review and serves as an overview of the different aspects of gastric cancer. The first section aims to clarify the main aspects of tumorigenesis, such as the role of inflammation linked to the presence

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Vincenzo Canzonieri Antonio Giordano Editors

Gastric Cancer In The Precision Medicine Era Diagnosis and Therapy

Current Clinical Pathology Series Editor Antonio Giordano MD PhD Philadelphia, PA, USA

More information about this series at http://www.springer.com/series/7632

Vincenzo Canzonieri Antonio Giordano Editors

Gastric Cancer In The Precision Medicine Era Diagnosis and Therapy

Editors Vincenzo Canzonieri Pathology Unit and Biobank CRO-Aviano, IRCCS, National Cancer Institute Aviano Italy University of Trieste Trieste TS Italy Department of Biology Temple University Philadelphia, PA USA

Antonio Giordano Sbarro Institute for Cancer Research and Molecular Medicine Department of Biology Temple University Philadelphia, PA USA Department of Medicine Surgery and Neuroscience University of Siena Siena Italy

ISSN 2197-781X     ISSN 2197-7828 (electronic) Current Clinical Pathology ISBN 978-3-030-04860-0    ISBN 978-3-030-04861-7 (eBook) https://doi.org/10.1007/978-3-030-04861-7 Library of Congress Control Number: 2018962131 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana Press imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Preface

Gastric cancer is an aggressive disease that represents a serious problem and has a daunting impact on global health. Despite an appreciable decrease in incidence over the last several decades, gastric cancer remains one of the most common types of cancer in the world. In recent years, a great progress has been made in understanding the pathogenesis of gastric cancer, especially regarding the importance of Helicobacter pylori and its associated ­inflammatory response. Furthermore, for early and advanced gastric cancers, appropriate treatments have been implemented to