Cancer Epigenetics for Precision Medicine Methods and Protocols
This volume discusses certain epigenetic changes recognized in early carcinogenic lesions and different tumors, as well as factors that alter the epigenome and epigenetic profile such as diet, alcohol, immunity, circadian rhythm, and more. The chapters in
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Ramona G. Dumitrescu Mukesh Verma Editors
Cancer Epigenetics for Precision Medicine Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Cancer Epigenetics for Precision Medicine Methods and Protocols
Edited by
Ramona G. Dumitrescu Kelly Government Solutions, Bethesda, MD, USA
Mukesh Verma Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Editors Ramona G. Dumitrescu Kelly Government Solutions Bethesda, MD, USA
Mukesh Verma Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health Bethesda, MD, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-8750-4 ISBN 978-1-4939-8751-1 (eBook) https://doi.org/10.1007/978-1-4939-8751-1 Library of Congress Control Number: 2018951780 © Springer Science+Business Media, LLC, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface A new era in medical research commenced when President Obama announced the new initiative in Precision Medicine at the State of the Union Address in January 2015. “Tonight, I’m launching a new Precision Medicine Initiative to bring us closer to curing diseases like cancer and diabetes—and to give all of us access to the personalized information we need to keep ourselves and our families healthier.” —President Barack Obama, State of the Union Address, January 20, 2015 President Obama’s research initiati
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