Genetically Defined Animal Models of Neurobehavioral Dysfunctions
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Genetically Defined Animal Models of Neurobehavioral Dysfunctions
Peter Driscoll Editor
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Springer Science+Business Media, LLC
Peter Driscoll ETH - Zentrum Laboratorium für vergleichende Physiologie und Verhaltensbiologie CH-8092 Zürich Switzerland Library of Congress Cataloging-in-Publication Data Genetically defined animal models of neurobehavioral dysfunctions I Peter Driscoll, editor. p. cm. Includes bibliographical references and index. ISBN 978-1-4899-6734-3 (h : alk. paper). -ISBN 978-1-4899-6734-3 (alk. paper) l. Mental illness-Genetic aspects-Animal models. 2. Nervous system-Diseases-Genetic aspects-Animal models. I. Driscoll, Peter, 1938[DNLM: l. Central Nervous System Diseases-genetics. 2. Disease Models, Animal. 3. Models, Genetic. WL 300 G3263] RC455.4.G4G48 1992 616.8'0442--dc20 91-33332 DNLM/DLC for Library of Congress CIP Printedon acid-free paper. © Springer Science+Business Media New York 1992
Originally published by Birkhäuser Boston in 1992 Softcover reprint of the hardcover Ist edition 1992 Copyright is not claimed for works of U. S. Govemment employees. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transrnitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission of the copyright owner. The use of general descriptive names, trademarks, etc. in this publication even ifthe former arenot especially identified, is nottobe taken as a sign that such names, as understood by the Trade Marks and Merchandise Marks Act, may accordingly be used freely by anyone. While the advice and information in this book are believed tobe true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Permission to photocopy for intemal or personal use, or the intemal or personal use of specific clients, is granted by Birkhäuser Boston for libraries and other users registered with the Copyright Clearance Center (CCC), provided that the base fee of $0.00 per copy, plus $0.20 per page is paid directly to CCC, 21 Congress Street, Salem, MA 01970, U.S.A. Special requests should be addressed directly to Birkhäuser Boston, 675 Massachusetts Avenue, Cambridge, MA 02139, U.S.A. ISBN 978-1-4899-6734-3 ISBN 978-1-4899-6732-9 (eBook) DOI 10.1007/978-1-4899-6732-9 Typeset by ATLIS Graphics, Mechanicsburg, PA. 9 8 7 6 5 4 3 2 1
Contents
List of Contributors
. iii
Introduction Peter Driscoll
. vii
Mouse Models of Human Trisomy 21 (Down Syndrome) Christoph N. Berger, Ting-Ting Huang, and Charles J. Epstein . . . . . . . . 1 Genetic Animal Models of Krabbe Disease Kinuko Suzuki and Kunihiko Suzuki . . . . . . . . . . . . . . . . . . . . . 24 Genetically Defined Myelin Disorders Ravina Simons and lohn R. Riordan ...
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Genetic Mutations Affecting Murine Cerebellar Structure and
