Glioblastoma Molecular Mechanisms of Pathogenesis and Current Therap
Glioblastoma, the deadliest of all primary brain tumors, is heterogenic and has very complex pathology and multiple mechanisms of cell proliferation and growth. This book describes all the latest concepts about the molecular mechanisms of pathogenesis of
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Glioblastoma
Molecular Mechanisms of Pathogenesis and Current Therapeutic Strategies
Glioblastoma
Swapan K. Ray Editor
Glioblastoma Molecular Mechanisms of Pathogenesis and Current Therapeutic Strategies
Editor Swapan K. Ray Department of Pathology, Microbiology, and Immunology University of South Carolina School of Medicine Columbia, SC USA [email protected]
ISBN 978-1-4419-0409-6 e-ISBN 978-1-4419-0410-2 DOI 10.1007/978-1-4419-0410-2 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2009927498 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Glioblastoma is the most malignant brain tumor that even now remains incurable. It is such a deadly disease that patients in most cases do not survive more than a few months after the diagnosis. Our understanding of the cellular and molecular mechanisms of the formation of glioblastoma is rapidly advancing so as to provide us clues for devising rational therapeutic strategies for the treatment of this malignancy. It is important that we continue to increase our knowledge about the aberrant molecular markers for pathogenesis of this devastating disease and thereby explore new areas ultimately to find successful therapeutic strategies. This book has a collection of chapters that include the latest understandings of histopathology, molecular genetics, aberrant signaling pathways, cytoskeleton dynamics, epigenetics, and role of stem cells in gliomagenesis, and also promising treatment strategies with the contributions from the prominent basic scientists and clinicians, who persistently work hard to make a difference and give fresh hope to the glioblastoma patients to survive longer. Various approaches such as sophisticated imaging techniques, improved surgical procedures, and new strategies for radiation therapy, combination chemotherapy, immunotherapy, chemoimmunotherapy, dietary therapy, and nanobiotherapy are being explored for the treatment of glioblastoma. All the contributors to this book have explicated their earnest desire to make use of the latest knowledge about the pathogenesis of glioblastoma to indicate the novel targets and innovative therapeutic strategies. It is keenly contemplated that this book wil
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