Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome
This comprehensive book reviews our current state of knowledge about the pathogenesis of idiopathic nephrotic syndrome (INS), which comprises a heterogeneous group of diseases with distinct histological characteristics, such as minimal-change nephrotic sy
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Kazunari Kaneko Editor
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Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome
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Kazunari Kaneko Editor
Molecular Mechanisms in the Pathogenesis of Idiopathic Nephrotic Syndrome
Editor Kazunari Kaneko Department of Pediatrics Kansai Medical University Hirakata, Osaka Japan
ISBN 978-4-431-55269-7 ISBN 978-4-431-55270-3 DOI 10.1007/978-4-431-55270-3
(eBook)
Library of Congress Control Number: 2015954087 Springer Tokyo Heidelberg New York Dordrecht London © Springer Japan 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer Japan KK is part of Springer Science+Business Media (www.springer.com)
Preface
Idiopathic nephrotic syndrome (INS) is one of the most common kidney diseases, comprising a heterogenous group of conditions including distinct histological findings such as minimal-change nephrotic syndrome (MCNS), focal segmental glomerulosclerosis (FSGS), and idiopathic membranous nephropathy (IMN). The pathogenesis of INS remains unclear, as the word “idiopathic” indicates. Historically, T-cell dysfunction has been thought to have an important role in the pathogenesis of MCNS, and many researchers explored circulating vascular permeability factors related to T-cell dysfunction. This approach reached a dead-end in the 1990s. Recent advances in molecular biology in the 2000s have enabled us to speculate that the interactions between visceral glomerular epithelial cells (podocytes) and several molecules are important in the pathogenesis of INS. In the meantime, the rapid pace of scientific progress occasionally sinks to a state of chaos, and the pathogenetic research in INS corresponds to such chaotic status. As scientists should work together, share resources, and expedite the design of protocols to evaluate the putative factors, this book intends to review our current knowledge in the pathogenesis of INS in order to promote the research in this field. This book is a humble attempt to
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