Nuclear Receptors Methods and Experimental Protocols
This volume presents valuable techniques for studying the class of ligand-activated transcription factors known as nuclear receptors. After a brief overview of the history of the field, chapters cover methods to detect the receptors and their mRNAs in var
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Mostafa Z. Badr Editor
Nuclear Receptors Methods and Experimental Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Nuclear Receptors Methods and Experimental Protocols
Edited by
Mostafa Z. Badr School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA
Editor Mostafa Z. Badr School of Pharmacy University of Missouri-Kansas City Kansas City, MO, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-9194-5 ISBN 978-1-4939-9195-2 (eBook) https://doi.org/10.1007/978-1-4939-9195-2 Library of Congress Control Number: 2019933562 © Springer Science+Business Media, LLC, part of Springer Nature 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Nuclear receptors (NRs) are a class of ligand-activated transcription factors. These receptors control numerous biological functions, making them a major target in treating a multitude of diseases, including inflammation, cancer, diabetes, aging, Alzheimer’s, and many other pathological conditions. Consequently, NR ligands are in the center of effort of many researchers in the field of drug discovery and development. In this edition of Methods in Molecular Biology, we present an array of valuable methods and protocols authored by a constellation of prominent researchers in the field of nuclear receptors. The included chapters cover a brief overview of the history of the field and methods to detect the receptors and their mRNAs in various tissues. In addition, there are
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