Lipid-Activated Nuclear Receptors Methods and Protocols
This book covers a wide range of state-of-the-art methodologies and detailed protocols currently used to study the actions that lipid-activated nuclear receptors and their co-regulators have in tissues and immune cell types considered classic metabolic “p
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Matthew C. Gage Inés Pineda-Torra Editors
Lipid-Activated Nuclear Receptors Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Lipid-Activated Nuclear Receptors Methods and Protocols
Edited by
Matthew C. Gage and Inés Pineda-Torra Division of Medicine, Centre for Cardiometabolic Medicine, University College London, London, UK
Editors Matthew C. Gage Division of Medicine Centre for Cardiometabolic Medicine University College London London, UK
Ine´s Pineda-Torra Division of Medicine Centre for Cardiometabolic Medicine University College London London, UK
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-9129-7 ISBN 978-1-4939-9130-3 (eBook) https://doi.org/10.1007/978-1-4939-9130-3 Library of Congress Control Number: 2019930086 © Springer Science+Business Media, LLC, part of Springer Nature 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Nuclear receptors comprise a family of ligand-activated transcription factors with crucial roles in the maintenance of cholesterol and lipid homeostasis (including biosynthesis, catabolism, and uptake by tissues and cells) while having multiple actions on innate and adaptive immunity. Indeed, the transcriptional regulation of ligand-receptor complexes constitutes an integral part of the signal transduction exerted by the lipophilic ligands of these receptors. This is exemplified by the fact that nuclear receptor aberrant activation or function has been implicated in a wid
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