NMDA Receptors Methods and Protocols
This volume explores the latest techniques used by researchers to help them better understand the NMDAR structure-function relations, principles, and rules that govern how NMDARs operate in brain processing. The volume includes a detailed introductory cha
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Nail Burnashev Pierre Szepetowski Editors
NMDA Receptors Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
NMDA Receptors Methods and Protocols
Edited by
Nail Burnashev and Pierre Szepetowski Mediterranean Institute of Neurobiology (INMED), Aix-Marseille University INSERM U901, Marseille, France
Editors Nail Burnashev Mediterranean Institute of Neurobiology (INMED) Aix-Marseille University INSERM U901 Marseille, France
Pierre Szepetowski Mediterranean Institute of Neurobiology (INMED) Aix-Marseille University INSERM U901 Marseille, France
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7320-0 ISBN 978-1-4939-7321-7 (eBook) DOI 10.1007/978-1-4939-7321-7 Library of Congress Control Number: 2017949681 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface This book is on N-methyl-D-aspartate receptors (NMDARs), and more precisely on the methods that can be used to study NMDARs at various levels. NMDARs are cation channels that are gated by the major excitatory neurotransmitter glutamate. NMDAR-mediated signaling is involved in normal development, plasticity, learning, memory, and high cognitive functions. NMDARs play an important role in temporal integration of neuronal network activity and long-term alterations in synaptic structure and function. There is long known association of NMDAR dysfunctions with various neurodevelopmental disorders and excitotox
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