Hematopathology Genomic Mechanisms of Neoplastic Diseases
Hematopathology: Genomic Mechanisms of Neoplastic Diseases will keep physicians abreast of the rapid and complex changes in genomic medicine, as exemplified by the molecular pathology of hematologic malignancies. This timely volume will update physicians
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Series Editors William B. Coleman Gregory J. Tsongalis
For further volumes: http://www.springer.com/series/8176
Domnita Crisan Editor
Hematopathology Genomic Mechanisms of Neoplastic Diseases
Editor Domnita Crisan William Beaumont Hospital Department of Clinical Pathology Molecular Pathology Lab 3601 West 13 Mile Road 48073-6769 Royal Oak, Michigan USA [email protected]
ISBN 978-1-60761-261-2 e-ISBN 978-1-60761-262-9 DOI 10.1007/978-1-60761-262-9 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010931434 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
I dedicate this book to my mother who gave me her gene for optimism, to my brave father who lost his life fighting communists, and to my husband, Dan, who offered his loving support, with patience and enthusiasm during work on this book and my entire professional career
Preface
Hematopathology: Genomic Mechanisms of Neoplastic Diseases in the book series Molecular and Translational Medicine addresses our current knowledge of genomics as applied to the pathogenesis, diagnosis, prognosis, monitoring, and targeted therapy of hematologic malignancies. Hematology has been at the vanguard of the application of molecular technologies in diagnosis, classification, risk stratification, and use of molecularly defined therapeutic targets. These advances in molecular technologies, diagnostics, and gene-related therapy have seen an extraordinary rapid pace since the completion of the Human Genome Project. Hematology has integrated the discoveries of genomic lesions underlying hematologic malignancies and applied the tools of molecular pathology, making them essential in clinical practice. The scope of this book is to keep pathologists and clinicians abreast of the rapid and complex changes in genomic medicine, as exemplified by the molecular pathology of leukem
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