Signal Transduction: Pathways, Mechanisms and Diseases
This book was adapted from graduate courses on signal transduction taught by the editor, where the need for a good overview of recent developments on each of the topics being discussed became apparent. Given the wide range of research topics in signaling,
- PDF / 11,775,063 Bytes
- 428 Pages / 439.37 x 666.142 pts Page_size
- 1 Downloads / 232 Views
Ari Sitaramayya Editor
Signal Transduction: Pathways, Mechanisms and Diseases
Editor Ari Sitaramayya Professor of Biomedical Sciences 423 DHE Eye Research Institute Oakland University Rochester, MI 48309 USA [email protected]
ISBN 978-3-642-02111-4 e-ISBN 978-3-642-02112-1 DOI 10.1007/978-3-642-02112-1 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2009928304 # Springer-Verlag Berlin Heidelberg 2010 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover illustration: Cellular and subcellular detection of M 2 receptors in striatal neurons; see Fig. 2.1 in Chap. 2 ‘‘Regulation of Intraneuronal Trafficking of G-Protein-Coupled Receptors by Neurotransmitters In Vivo’’ by Ve´ronique Bernard Cover design: WMXDesign GmbH, Heidelberg, Germany Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
For Usha, Vani, and Aruna
Preface
Teaching a graduate course on signal transduction in the fall of 2007 was very enjoyable. Each week, my students and I discussed a recently published research paper in some area of signaling, argued about the appropriateness of the methodology used in the research, the design of the experiments, and whether the conclusions drawn were supported by the results presented. Finally, each student was asked to list what was good and what was deficient in the paper and whether she/he would have accepted or rejected it had she/he reviewed it for publication. For a good number of recent papers, a consistent complaint of the students was that the background to the research was not adequately described. It can of course be argued that students should research the background. Either way, the need for a good source of background material in order to appreciate the research presented in a paper became apparent to me and was the inspiration for developing this book. The goal in bringing this book was to provide students with a review of recent developments in specific areas of current interest in signal transduction, sufficiently in depth to make recent research publications accessible. However, given the wide range of research topics being investigated today in signaling, a choice had to be made to focus on a select few. This choice was made n
Data Loading...
