Heparin
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Heparin-induced thrombocytopenia: case report A 25-year-old man developed heparin-induced thrombocytopenia during treatment with heparin. The man had a motor vehicle accident, was admitted to the surgical ICU for sternal fractures, traumatic brain injury and multiple rib fractures. On day 2, he became hypoxic, and was intubated. However, hypoxia persisted; hence, venovenous extracorporeal membrane oxygenation (vvECMO) was initiated for respiratory function support. He started receiving heparin [route and dosage not stated], and subsequently, his platelet count dropped. A platelet antibody test for heparin showed positive results. Hence, the man’s therapy with heparin was changed to argatroban. At the same time, the serotonin release assay showed negative results. Therefore, the man’s therapy with heparin was re-started, and his platelet count again decreased. A serotonin release assay was re-sent, and it showed positive results. Therefore, he was diagnosed with heparin-induced thrombocytopenia. Afterwards, he was weaned from ECMO and ventilator, and on day 64, he was discharged from hospital [outcome not stated]. Author comment: "Here, we present a case of [heparininduced thrombocytopenia] patient whose initial [serotonin release assay] was negative, which subsequent [serotonin release assay] test was positive." Murphy C, et al. How much should we rely on the serotonin release assay test in managing an hit patient?. Critical Care Medicine 47 (Suppl. 1): 234 abstr. 507, No. 1, Jan 2019. Available from: URL: http:// 803432782 doi.org/10.1097/01.ccm.0000550792.31188.1c [abstract] - USA
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Reactions 9 Nov 2019 No. 1778
