The Oncogenic Role of Hepatitis C Virus

Persistent infection with hepatitis C virus (HCV) is a major risk factor for hepatocellular carcinoma (HCC). Accumulating evidence suggests that not only inflammation and subsequent fibrosis but also HCV itself are associated with hepatocarcinogenesis. To

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T.-C. Wu Mei-Hwei Chang Kuan-Teh Jeang   Editors

Viruses and Human Cancer From Basic Science to Clinical Prevention Second Edition

Recent Results in Cancer Research Volume 217 Series Editors Alwin Krämer, German Cancer Research Center, Heidelberg, Germany Jiade J. Lu, Shanghai Proton and Heavy Ion Center, Shanghai, China

More information about this series at http://www.springer.com/series/392

T.-C. Wu  Mei-Hwei Chang  Kuan-Teh Jeang Editors

Viruses and Human Cancer From Basic Science to Clinical Prevention Second Edition

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Editors T.-C. Wu School of Medicine Johns Hopkins University School of Medicine Baltimore, MD, USA

Mei-Hwei Chang Hepatitis Research Center National Taiwan University Hospital Taipei, Taiwan

Kuan-Teh Jeang Molecular Virology Section, Laboratory of Mole National Institute of Allergy and Infect Bethesda, MD, USA

ISSN 0080-0015 ISSN 2197-6767 (electronic) Recent Results in Cancer Research ISBN 978-3-030-57361-4 ISBN 978-3-030-57362-1 (eBook) https://doi.org/10.1007/978-3-030-57362-1 1st edition: © Springer-Verlag Berlin Heidelberg 2014 2nd edition: © Springer Nature Switzerland AG 2021 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Contents

An Introduction to Virus Infections and Human Cancer . . . . . . . . . . . . John T. Schiller and Douglas R. Lowy

1

Epidemiology of Virus Infection and Human Cancer . . . . . . . . . . . . . . . Chien-Jen Chen, San-Lin You, Wan-Lun Hsu, Hwai-I Yang, Mei-Hsuan Lee, Hui-Chi Chen, Yun-Yuan Chen, Jessica Liu, Hui-Han Hu, Yu-Ju Lin, Yu-Ju Chu, Yen-Tsung Huang, Chun-Ju Chiang, and Yin-Chu Chien

13

Mechanisms of Hepatitis B Virus-Induced Hepatocarcinogenesis . . . . . . Jiyoung Lee, Kuen-Nan Tsai, and Jing-hsiung James Ou

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