Heterologous Expression of Membrane Proteins Methods and Protocols
Membrane proteins play a key role in numerous pathologies such as cancer, cystic fibrosis, epilepsy, hyperinsulinism, and Alzheimer’s disease, yet studies on these and other disorders are hampered by a lack of information about the proteins involved. In H
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Molecular Biology™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For other titles published in this series, go to www.springer.com/series/7651
Heterologous Expression of Membrane Proteins Methods and Protocols
Edited by
Isabelle Mus-Veteau Institut of Developmental Biology and Cancer, UMR CNRS 6543 Université de Nice-Sophia Antipolis, Parc Valrose, Nice, France
Editor Isabelle Mus-Veteau, Ph.D. Institut of Developmental Biology and Cancer, UMR CNRS 6543 Université de Nice-Sophia Antipolis Parc Valrose, Nice France [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-60761-343-5 e-ISBN 978-1-60761-344-2 DOI 10.1007/978-1-60761-344-2 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2009932113 © Humana Press, a part of Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Cover illustration: The background art is derived from Figure 5 in Chapter 12. Printed on acid-free paper Humana Press is a part of Springer Science+Business Media (www.springer.com)
Preface Membrane proteins account for roughly 30% of all open reading frames in fully sequenced genomes. These proteins are of central importance to living cells. They are required for transport processes, sensing changes in the cellular environment, transmission of signals, and control of cell–cell contacts. These proteins are implicated in numerous pathologies, like cancer, cystic fibrosis, epilepsy, hyperinsulinism, heart failure, hypertension and Alzheimer disease, but studies of these and other disorders are hampered by a lack of information about the proteins involved. Knowing the structure of membrane proteins is an essential prerequisite for understanding how these proteins function and, further, how their functions can be modified by small molecules. This is of paramount importance in the pharmaceutical industry, which produces many drugs that bind to memb
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