High Asymmetric Dimethylarginine (ADMA) Levels in Patients with Brucellosis
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High Asymmetric Dimethylarginine (ADMA) Levels in Patients with Brucellosis Zafer Mengeloglu,1,5 Mahmut Sünnetcioglu,2 Mehmet Tosun,3 Abdülkadir Kücükbayrak,4 Mehmet Resat Ceylan,2 Ali Irfan Baran,2 Mustafa Karahocagil,2 and Hayrettin Akdeniz4
Abstract—Asymmetric dimethylarginine (ADMA) is the main endogenous inhibitor of nitric oxide synthase and is considered to be associated with endothelial dysfunction. Brucellosis, a zoonotic disease caused by Brucella spp., can manifest as vasculopathy. The present study was performed to investigate the relationship between ADMA and brucellosis. Serum samples from 39 patients with an accurate diagnosis of brucellosis and from 18 healthy control individuals were included in this study. ADMA levels were significantly higher in the patient group than the controls (P
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