Transporters as Targets for Drugs
M. Bingham • S. Napier: Overview: Transporters as Targets for Drug Discovery I. Sylte • A.W. Ravna • G. Sager • S.G. Dahl: Membrane Transporters: Structure, Function and Targets for Drug Design G.A. Whitlock • M.D. Andrews • A.D. Brown • P.V Fish • A. Sto
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Editorial Board: P. R. Bernstein · A. Buschauer · G. J. Georg · J. A. Lowe · H. U. Stilz
Transporters as Targets for Drugs Volume Editors: Susan Napier · Matilda Bingham
With contributions by M. D. Andrews · G. Antoni · M. Bingham · R. J. Bridges A. D. Brown · Z. Chen · S. G. Dahl · P. V. Fish · R. Gilfillan H. Hall · J. L. Katz · J. Kerr · S. Napier · A. Hauck Newman S. A. Patel · A. W. Ravna · G. Sager · P. Skolnick · J. Sörensen A. Stobie · I. Sylte · F. Wakenhut · G. Walker · G. A. Whitlock G. Wishart · J. Yang
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Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the new topic-related series should cover all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In references Topics in Medicinal Chemistry is abbreviated Top Med Chem and is cited as a journal. Springer WWW home page: springer.com Visit the TIMC content at springerlink.com
ISSN 1862-2461 e-ISSN 1862-247X ISBN 978-3-540-87911-4 ISBN 978-3-540-87912-1 (eBook) DOI 10.1007/978-3-540-87912-1 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2009926137 c Springer-Verlag Berlin Heidelberg 2009 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover design: WMXDesign GmbH, Heidelberg Typesetting and Production: le-tex publishing services oHG, Leipzig Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Volume Editors Dr. Susan Napier
Dr. Matilda Bingham
Schering Plough Corporation Newhouse, Motherwell, ML1 5SH United Kingdom [email protected]
Schering Plough Corporation Newhouse, Motherwell, ML1 5SH United Kingdom [email protected]
Editorial Board Dr. Peter R. Bernstein
Prof. Dr. Gunda J. Georg
AstraZ
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