HIV-1 Proteomics From Discovery to Clinical Application
The development of proteomic analyses using advanced mass spectrometry techniques has revolutionized the way proteins are studied, namely, as individual molecules within a complex system. HIV-1 Proteomics: From Discovery to Clinical Application comp
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Proteomics From Discovery to Clinical Application
HIV-1 Proteomics
David R.M. Graham • David E. Ott Editors
HIV-1 Proteomics From Discovery to Clinical Application
Editors David R.M. Graham Department of Molecular and Comparative Pathobiology The Johns Hopkins University School of Medicine Baltimore, MD, USA
David E. Ott Leidos Biomedical Research, Inc. Frederick National Laboratory for Cancer Research Frederick, MD, USA
ISBN 978-1-4939-6540-3 ISBN 978-1-4939-6542-7 DOI 10.1007/978-1-4939-6542-7
(eBook)
Library of Congress Control Number: 2016952094 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
We dedicate this book to Louis Edwin Henderson Ph.D. (1934–2013). Lou: a pioneer in retroviral protein chemistry, a mentor to so many, trusted colleague, a friend, and a tireless AIDS fighter.
Preface
The focus of this book is to provide a clear understanding of how the proteins in HIV-1 can be analyzed by proteomic approaches and cover some of the accomplishments produced by this powerful technique. Being in the field, we believe that much can be learned from the comprehensive study of proteins and their modifications. Throughout our combined careers, we have seen many scientific advances that were initiated by protein-focused research of HIV-1. To convey this appreciation for this topic, we have set out to compile expert views of HIV-1 proteomics. The target audiences for this book are those non-expert readers who desire a comprehensive but technically understandable view of the field, those in associated fields who want a deeper theoretical understanding and an entree into in-depth technical literature and resources through review references, and experts in the field who are interested in key points of interest and conflict in HIV-1 proteomics as well as current directions in the
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