Proteomics for Biomarker Discovery Methods and Protocols
This volume presents modern and enhanced methods that detail techniques to perform proteomics analyses dedicated to biomarker discovery for human health. Chapters guide readers through pre/post analytical factors, protocols for the preparation of extracel
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Virginie Brun Yohann Couté Editors
Proteomics for Biomarker Discovery Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Proteomics for Biomarker Discovery Methods and Protocols
Edited by
Virginie Brun and Yohann Couté Université Grenoble Alpes, CEA, Inserm, BGE U1038, Grenoble, France
Editors Virginie Brun Universite´ Grenoble Alpes CEA, Inserm, BGE U1038 Grenoble, France
Yohann Coute´ Universite´ Grenoble Alpes CEA, Inserm, BGE U1038 Grenoble, France
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-9163-1 ISBN 978-1-4939-9164-8 (eBook) https://doi.org/10.1007/978-1-4939-9164-8 Library of Congress Control Number: 2019933724 © Springer Science+Business Media, LLC, part of Springer Nature 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Recent progress in the fields of instrumentation, pre-analytical and analytical methods, and data treatment has significantly improved the performance of mass spectrometry (MS)based discovery proteomics analysis and the range of its applications. In biomedical research, discovery proteomics analysis is extensively used to characterize cellular, tissue, and biological fluid proteomes to extract information advancing our understanding of pathogenic mechanisms and to identify new biomarkers for diagnostic, prognostic, or therapeutic follow-up purposes. Discovery proteomics approaches to identify new biomarker candidates involve the sequential application of several steps con
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