Hot Topics in Infection and Immunity in Children IV

Hot Topics in Infection and Immunity in Children IV contains chapters based on lectures given by speakers at the “Infection and Immunity in Children” course, held in June 2006 at Keble College, Oxford. It was the fourth annual course of this name and this

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ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R. COHEN, The Weizmann Institute of Science ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research JOHN D. LAMBRIS, University of Pennsylvania RODOLFO PAOLETTI, University of Milan Recent Volumes in This Series Volume 601 IMMUNE MEDIATED DISEASES: FROM THEORY TO THERAPY Edited by Michael R. Shurin Volume 602 OSTEOIMMUNOLOGY: INTERACTIONS OF THE IMMUNE AND SKELETAL SYSTEMS Edited by Yongwon Choi Volume 603 THE GENUS YERSINIA: FROM GENOMICS TO FUNCTION Edited by Robert D. Perry and Jacqueline D. Fetherson Volume 604 ADVANCES IN MOLECULAR ONCOLOGY Edited by Fabrizio d’Adda di Gagagna, Susanna Chiocca, Fraser McBlane and Ugo Cavallaro Volume 605 INTEGRATION IN RESPIRATORY CONTROL Edited by Marc Poulin and Richard Wilson Volume 606 BIOACTIVE COMPONENTS OF MILK Edited by Zsuzsanna Bösze Volume 607 EUKARYOTIC MEMBRANES AND CYTOSKELETON: ORIGINS AND EVOLUTION Edited by Gáspár Jékely Volume 608 BREAST CANCER CHEMOSENSITIVITY Edited by Dihua Yu and Mien-Chie Hung Volume 609 HOT TOPICS IN INFECTION AND IMMUNITY IN CHILDREN IV

Edited by Adam Finn and Andrew J. Pollard A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.

Adam Finn • Andrew J. Pollard Editors

Hot Topics in Infection and Immunity in Children IV

Adam Finn Institute of Child Life and Health UBHT Education Centre University of Bristol, UK Upper Maudlin Street Bristol BS2 8AE

ISBN: 978-0-387-73959-5

Andrew Pollard University of Oxford Department of Paediatrics Level 4, John Radcliffe Hospital Oxford, OX3 9DU United Kingdom

e-ISBN: 978-0-387-73960-1

Library of Congress Control Number: 2007934263 © 2008 Springer Science+Business Media, LLC All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY - 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper. 9 8 7 6 5 4 3 2 1 springer.com

Preface

This book contains chapters based on lectures given by speakers at the “Infection and Immunity in Children” course, held in June 2006 at Keble College, Oxford. It was the fourth annual course of this name and this is the fourth book in the series as well. Together the courses and books have become important components of the