Seroprevalence and immunity of SARS-CoV-2 infection in children and adolescents in schools in Switzerland: design for a
- PDF / 575,075 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 60 Downloads / 138 Views
(0123456789().,-volV)(0123456789().,-volV)
ORIGINAL ARTICLE
Seroprevalence and immunity of SARS-CoV-2 infection in children and adolescents in schools in Switzerland: design for a longitudinal, school-based prospective cohort study Agne Ulyte1 • Thomas Radtke1 • Ire`ne A. Abela2 • Sarah R. Haile1 • Julia Braun1 • Ruedi Jung1 Christoph Berger3 • Alexandra Trkola2 • Jan Fehr1 • Milo A. Puhan1 • Susi Kriemler1
•
Received: 10 September 2020 / Revised: 17 September 2020 / Accepted: 17 September 2020 The Author(s) 2020
Abstract Objectives This longitudinal cohort study aims to assess the extent and patterns of seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in school-attending children, and their parents and school personnel. It will examine risk factors for infection, the relationship between seropositivity and symptoms, and temporal persistence of antibodies. Methods The study (Ciao Corona) will enroll a regionally representative, random sample of schools in the canton of Zurich, where 18% of the Swiss population live. Children aged 5–16 years, attending primary and secondary schools, and their parents and school personnel are invited. Venous blood and saliva samples are collected for serological testing in June/July 2020, in October/November 2020, and in March/April 2021. Bi-monthly questionnaires will cover SARS-CoV-2 symptoms and tests, health, preventive behavior, and lifestyle information. Hierarchical Bayesian logistic regression models will account for sensitivity and specificity of the serological tests in the analyses and complex sampling structure, i.e., clustering within classes and schools. Results and conclusions This unique school-based study will allow describing temporal trends of immunity, evaluate effects of preventive measures and will inform goal-oriented policy decisions during subsequent outbreaks. Trial registration ClinicalTrials.gov Identifier: NCT04448717, registered June 26, 2020. https://clinicaltrials.gov/ct2/ show/NCT04448717. Keywords SARS-CoV-2 COVID-19 Children Adolescents School Protocol
Introduction Decisions on school openings or closures during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic vary greatly across and within countries. While some countries kept schools mostly open (e.g., Sweden, Australia) or reopened early (e.g., Denmark), others opted for prolonged closures with decisions on reopening pending (e.g., the USA, Italy, Ireland). Early school
Agne Ulyte and Thomas Radtke have shared first authorship.
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00038-020-01495-z) contains supplementary material, which is available to authorized users. Extended author information available on the last page of the article
closures in response to the pandemic were partly guided by evidence of transmission of other viruses, such as influenza (Cauchemez et al. 2009; Litvinova et al. 2019), but the current reports suggest that the susceptibility and transmis
Data Loading...
