Human Cell Transformation Role of Stem Cells and the Microenvironmen
Rhim and Kremer’s state-of-the-art volume on Human Cell Transformation: Role of Stem Cells and the Microenvironment highlights the latest findings on the current state of human cell transformation model systems and provides the insight into the molecular
- PDF / 10,299,909 Bytes
- 239 Pages / 504.567 x 720 pts Page_size
- 1 Downloads / 201 Views
For further volumes: http://www.springer.com/series/5584
wwwwwwwwwwwwww
Johng S. Rhim • Richard Kremer Editors
Human Cell Transformation Role of Stem Cells and the Microenvironment
Editors Johng S. Rhim Department of Surgery Uniformed Services University of the Health Sciences Bethesda, MD, USA [email protected]
Richard Kremer Department of Medicine McGill University Health Centre Montreal, QC, Canada [email protected]
ISBN 978-1-4614-0253-4 e-ISBN 978-1-4614-0254-1 DOI 10.1007/978-1-4614-0254-1 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011935228 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
The role of carcinogenic agents in the development of human cancers is being defined using a variety of human cells as experimental model systems. Thus, the study of human cell transformation in culture by carcinogenic agents is of particular importance for understanding the cellular and molecular mechanisms underlying human carcinogenesis. A conference on “Human Cell Transformation: Role of Stem Cells and the Environment” was held at the McGill University Health Center, Montreal, Canada, on October 20–21, 2010. The aims of the conference were to present the state-of-the-art in the transformation of human cells in culture, as well as to provide insight into the molecular and cellular changes involved in the conversion of normal cells to a neoplastic state of growth (Fig. 1). The conference encompassed the most recent developments in human cell transformation including selected in vitro models, tumor xenografts, and transgenic preclinical models. The meeting provided a unique forum for the exchange of information in this important research field. Some of the novel topics to be addressed included: what is the relationship between normal and malignant phenotypes? what is the role of stem cells and the microenvironment in this process? what are the current approaches to identify and target the cancer cells at the different stages of tumor progression? The following topics were closely related to the theme of the conference: 1. Derivation of in vitro model systems (epithelial, fibroblastic, and hematopoietic). 2. Usefulness of defined in vitro model sys
Data Loading...
